MARCHF6 and UBE2G1

Number of citations of the paper that reports this interaction (PubMedID 15673284)
58

Data Source:
BioGRID (pull down)

		MARCHF6	UBE2G1
Description		membrane associated ring-CH-type finger 6	ubiquitin conjugating enzyme E2 G1
Image		No pdb structure
GO Annotations	Cellular Component	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment	Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cholesterol Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		ER Quality Control Compartment (ERQC)	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)
Interacting Genes		12 interacting genes: ADGRE2 BUD31 DIO2 MSMO1 MTNR1B RGS2 SQLE UBC UBE2D2 UBE2G1 UBE2G2 UBE2J2	24 interacting genes: AMFR APP CBL CRBN CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM2 TRIM63 UBA1 UBC UBE2E1 UBE3A ZRANB1
Entrez ID		10299	7326
HPRD ID		11095	03340
Ensembl ID		ENSG00000145495	ENSG00000132388
Uniprot IDs		O60337	P62253
PDB IDs			2AWF 6D68
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cholesterol Biosynthetic Process Post-translational Protein Modification ATP Binding Sterol Biosynthetic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Squalene Monooxygenase Activity Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Membrane Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Nucleotide Binding Negative Regulation Of Glycine Import Across Plasma Membrane Proteolysis Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity Thyroid Hormone Catabolic Process Steroid Biosynthetic Process C-4 Methylsterol Oxidase Activity Response To Biphenyl Catabolic Process ERAD Pathway Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adenylate Cyclase Inhibitor Activity	Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Protein Polyubiquitination Macromolecule Catabolic Process Protein Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein Monoubiquitination Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin-specific Protease Binding Zinc Ion Binding Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Signal Transduction Protein Alpha-1,2-demannosylation Metal Ion Binding Protein Deglycosylation Regulation Of Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Endoplasmic Reticulum Quality Control Compartment Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Catabolic Process ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Necrotic Cell Death Regulation Of Post-translational Protein Modification Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification
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