MARCH6 and UBE2G1

Number of citations of the paper that reports this interaction (PMID 15673284)
49

Data Source:
BioGRID (pull down)

		MARCH6	UBE2G1
Gene Name		membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2G 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein K48-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Body mass index ( 22446040)
Protein-Protein Interactions		3 interactors: DIO2 UBE2D2 UBE2G1	13 interactors: AMFR APP CBL DIO2 HUWE1 ITCH MARCH6 PARK2 RBCK1 RBX1 UBA1 UBE2E1 UBE3A
Entrez ID		10299	7326
HPRD ID		11095	03340
Ensembl ID		ENSG00000145495	ENSG00000132388
Uniprot IDs		O60337	P62253
PDB IDs			2AWF
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Thyroid Hormone Catabolic Process Catabolic Process Selenocysteine Incorporation Hormone Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Thyroid Hormone Generation Cellular Modified Amino Acid Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Thyroid Hormone Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Proteolysis Phenol-containing Compound Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Metabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Catabolic Process Protein Monoubiquitination Protein Metabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K29-linked Ubiquitination Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Catabolic Process Notch Signaling Pathway Negative Regulation Of JNK Cascade Protein K63-linked Ubiquitination Intracellular Receptor Signaling Pathway Viral Process Regulation Of Protein Ubiquitination Negative Regulation Of Stress-activated MAPK Cascade Histone Ubiquitination Positive Regulation Of Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Autoubiquitination Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Learning Or Memory Cognition Positive Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Sperm Entry Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Signaling
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