MARCHF6 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 19651899)
38

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		MARCHF6	DIO2
Description		membrane associated ring-CH-type finger 6	iodothyronine deiodinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Cholesterol Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming	Selenocysteine Incorporation Thyroid Hormone Generation Response To Lipopolysaccharide Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		ER Quality Control Compartment (ERQC)	Regulation of thyroid hormone activity Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS			Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		12 interacting genes: ADGRE2 BUD31 DIO2 MSMO1 MTNR1B RGS2 SQLE UBC UBE2D2 UBE2G1 UBE2G2 UBE2J2	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		10299	1734
HPRD ID		11095	09027
Ensembl ID		ENSG00000145495	ENSG00000211448
Uniprot IDs		O60337	A8K845 Q92813
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cholesterol Biosynthetic Process Post-translational Protein Modification ATP Binding Sterol Biosynthetic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Squalene Monooxygenase Activity Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Membrane Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Nucleotide Binding Negative Regulation Of Glycine Import Across Plasma Membrane Proteolysis Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity Thyroid Hormone Catabolic Process Steroid Biosynthetic Process C-4 Methylsterol Oxidase Activity Response To Biphenyl Catabolic Process ERAD Pathway Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adenylate Cyclase Inhibitor Activity	Post-translational Protein Modification Protein Modification Process Protein Polyubiquitination Proteolysis Protein Ubiquitination Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity G Protein-coupled Receptor Binding ER Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Cysteine-type Deubiquitinase Activity ERAD Pathway Macromolecule Metabolic Process Protein Deubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Removal Protein Aggregate Center Assembly Protein Catabolic Process Cysteine-type Peptidase Activity VCB Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Catabolic Process Hrd1p Ubiquitin Ligase Complex Response To Endoplasmic Reticulum Stress Negative Regulation Of Cholesterol Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Cholesterol Metabolic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Glycoprotein Metabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Ubiquitin Protein Ligase Binding Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding Regulation Of Autophagy Centrosome Duplication Protein Deglycosylation
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