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MARCH6 and DIO2
Number of citations of the paper that reports this interaction (PMID
19651899
)
20
Data Source:
BioGRID
(affinity chromatography technology, fluorescent resonance energy transfer)
MARCH6
DIO2
Gene Name
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
deiodinase, iodothyronine, type II
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Integral Component Of Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
Enzyme Binding
Ubiquitin Conjugating Enzyme Binding
Thyroxine 5'-deiodinase Activity
Selenium Binding
Ubiquitin Protein Ligase Binding
Biological Process
Protein K48-linked Ubiquitination
Selenocysteine Incorporation
Thyroid Hormone Generation
Cellular Nitrogen Compound Metabolic Process
Thyroid Hormone Metabolic Process
Hormone Biosynthetic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Pathways
Amine-derived hormones
Regulation of thyroid hormone activity
Thyroxine biosynthesis
Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Body mass index (
22446040
)
Protein-Protein Interactions
3 interactors:
DIO2
UBE2D2
UBE2G1
6 interactors:
MARCH6
UBE2G1
UBE2J1
USP20
USP33
WSB1
Entrez ID
10299
1734
HPRD ID
11095
09027
Ensembl ID
ENSG00000145495
ENSG00000211448
Uniprot IDs
O60337
A8K845
Q92813
Q9HCP7
PDB IDs
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Thyroid Hormone Catabolic Process
Catabolic Process
Selenocysteine Incorporation
Hormone Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Thyroid Hormone Generation
Cellular Modified Amino Acid Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Thyroid Hormone Metabolic Process
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Cellular Protein Metabolic Process
Hormone Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Proteolysis
Phenol-containing Compound Metabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Protein Metabolic Process
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K48-linked Deubiquitination
Cellular Protein Modification Process
Protein K63-linked Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasomal Protein Catabolic Process
Protein K48-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Proteolysis
Protein Deubiquitination
Protein Modification By Small Protein Removal
Catabolic Process
Protein Polyubiquitination
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Cellular Metabolic Process
Protein K63-linked Ubiquitination
Centrosome Duplication
ER-associated Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Regulation Of Proteolysis
Negative Regulation Of Protein Binding
Centrosome Cycle
Positive Regulation Of Protein Binding
Tagcloud
?
cga
deiodinase
hypothalamic
hypothalamus
intra
intraperitoneal
ko
littermates
mct
mct8
nbr
neuromedin
paracrine
pituitary
releasing
slc16a2
slight
t3
t4
thrb
thyroid
thyroidal
thyrotropin
thyroxine
trh
trhr
triiodothyronine
tsh
tshb
Tagcloud (Difference)
?
cga
deiodinase
hypothalamic
hypothalamus
intra
intraperitoneal
ko
littermates
mct
mct8
nbr
neuromedin
paracrine
pituitary
releasing
slc16a2
slight
t3
t4
thrb
thyroid
thyroidal
thyrotropin
thyroxine
trh
trhr
triiodothyronine
tsh
tshb
Tagcloud (Intersection)
?