EPB42 and DMTN

Number of citations of the paper that reports this interaction (PubMedID 8608138)
0

Data Source:
HPRD (in vivo)

		EPB42	DMTN
Description		erythrocyte membrane protein band 4.2	dematin actin binding protein
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cortical Cytoskeleton Cell Periphery Ankyrin-1 Complex	Cytoplasm Smooth Endoplasmic Reticulum Cytosol Cytoskeleton Actin Filament Plasma Membrane Endomembrane System Postsynaptic Density Spectrin-associated Cytoskeleton Actin Cytoskeleton Membrane Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Cytoplasmic Vesicle Cell Projection Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding	Actin Binding Signaling Receptor Binding Protein Binding Spectrin Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Cytoskeleton Organization Regulation Of Cell Shape Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Monoatomic Ion Homeostasis Multicellular Organismal-level Iron Ion Homeostasis	Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein-containing Complex Assembly Cellular Response To CAMP Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Miscellaneous transport and binding events
Drugs
Diseases		Hereditary spherocytosis (SPH)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494)	Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Gamma glutamyl transferase levels ( 33339817) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 30275531)
Interacting Genes		13 interacting genes: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12	16 interacting genes: ACTB ACTC1 APP CEP76 DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB TEX11 TRAF2
Entrez ID		2038	2039
HPRD ID		01517	00506
Ensembl ID		ENSG00000166947	ENSG00000158856
Uniprot IDs		P16452	Q08495
PDB IDs		7TVZ 7TW0 7TW1 7TW3 7TW5 7TW6 7UZS 7V0K 7V0Q 8CS9 8CSL 8CSW 8CTE	1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Spectrin Binding Spectrin-associated Cytoskeleton Structural Constituent Of Cytoskeleton Basolateral Plasma Membrane Cortical Cytoskeleton Regulation Of Actin Filament-based Process Ankyrin-1 Complex Monoatomic Anion Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Cytoskeleton Organization A Band BLOC-1 Complex Cytoplasmic Side Of Plasma Membrane Regulation Of Actin Cytoskeleton Organization Z Disc Cytoskeletal Anchor Activity Actin Cytoskeleton Organization Organelle Organization Enzyme Binding M Band Intracellular Monoatomic Ion Homeostasis Regulation Of Biological Quality Intracellular Monoatomic Cation Homeostasis Homeostatic Process Actin Filament-based Process Bicarbonate Transport Erythrocyte Development Actin Filament Capping Protein-membrane Adaptor Activity Monoatomic Cation Homeostasis Protein Localization To Plasma Membrane Monoatomic Ion Homeostasis Negative Regulation Of Actin Filament Depolymerization Localization Within Membrane Intracellular Chemical Homeostasis Regulation Of Cytoskeleton Organization Osteoclast Differentiation Protein Localization To Cell Periphery Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Protein Localization To T-tubule PH Elevation Regulation Of Actin Filament Organization Endomembrane System Cellular Homeostasis Regulation Of Interleukin-12 Production Myeloid Cell Development Cytoskeletal Protein Binding Regulation Of Organelle Organization	Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Endocytosis Positive Regulation Of Endocytosis Cytoskeleton Protein-containing Complex Cell Junction Organization Postsynapse Cellular Response To Epinephrine Stimulus Positive Regulation Of Transport Cellular Component Assembly Protein Tetramerization Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Response To Epinephrine Structural Constituent Of Cytoskeleton Actin Cytoskeleton Regulation Of Vesicle-mediated Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Neurotransmitter Uptake Cytoplasm Cytoskeleton Organization Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Metal Ion Transport Regulation Of Generation Of Precursor Metabolites And Energy Cortical Cytoskeleton Regulation Of Synaptic Vesicle Recycling Regulation Of Calcium Ion Transmembrane Transport Perinuclear Region Of Cytoplasm Regulation Of Protein Catabolic Process Amyloid Fibril Formation Microglial Cell Activation Negative Regulation Of Catabolic Process Cell Maturation Positive Regulation Of Small Molecule Metabolic Process Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Cell Cortex Regulation Of Cellular Component Organization Kinesin Binding Protein Kinase Binding Tau Protein Binding Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex
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