EPB42 and ANK1

Number of citations of the paper that reports this interaction (PMID 2968981)
19

Data Source:
HPRD (in vitro)

		EPB42	ANK1
Gene Name		erythrocyte membrane protein band 4.2	ankyrin 1, erythrocytic
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoskeleton Plasma Membrane Cortical Cytoskeleton	Nucleus Cytosol Cytoskeleton Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma Cortical Cytoskeleton M Band Sarcolemma Postsynaptic Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Spectrin Binding ATPase Binding
	Biological Process	Cell Morphogenesis Regulation Of Cell Shape Peptide Cross-linking Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Iron Ion Homeostasis	Porphyrin-containing Compound Biosynthetic Process Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Axon Guidance Positive Regulation Of Organelle Organization Monovalent Inorganic Cation Transport Maintenance Of Epithelial Cell Apical/basal Polarity Erythrocyte Development Iron Ion Homeostasis Protein Targeting To Plasma Membrane
Pathways			Interaction between L1 and Ankyrins CHL1 interactions Axon guidance Neurofascin interactions NrCAM interactions L1CAM interactions
Drugs
Diseases
GWAS			Glycated hemoglobin levels ( 20858683) Pulmonary function decline ( 22424883) Type 2 diabetes ( 22456796)
Protein-Protein Interactions		13 interactors: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12	18 interactors: BLOC1S6 CD44 EPB42 ITPR3 KCTD6 L1CAM NBPF3 NEDD8 NFASC OBSCN RHAG SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN
Entrez ID		2038	286
HPRD ID		01517	01693
Ensembl ID		ENSG00000166947	ENSG00000029534
Uniprot IDs		F5H563 P16452	B3KX39 P16157
PDB IDs			1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Chemotaxis Locomotion Axon Guidance Neuron Projection Development Blood Coagulation Hemostasis Neuron Development Bicarbonate Transport Axonogenesis Cell Morphogenesis Ion Homeostasis Axon Development Cell Development Regulation Of Body Fluid Levels Response To External Stimulus Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Protein Targeting To Plasma Membrane Wound Healing Erythrocyte Development Cell Projection Organization Regulation Of Intracellular PH Myeloid Cell Differentiation Regulation Of Cellular PH Neuron Projection Morphogenesis Actin Filament Capping Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Actin Filament Depolymerization Homeostatic Process Organelle Organization P38MAPK Cascade Positive Regulation Of Platelet Aggregation Protein Localization To T-tubule Muscle Cell Differentiation Vesicle-mediated Transport Regulation Of PH Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Establishment Of Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Cell Differentiation Chemical Homeostasis Cell Part Morphogenesis Generation Of Neurons Negative Regulation Of Protein Polymerization Protein Stabilization Protein Secretion By Platelet	Cell Development Anatomical Structure Morphogenesis Axon Guidance Movement Of Cell Or Subcellular Component Neuron Projection Development Locomotion Axonogenesis Anatomical Structure Development Bicarbonate Transport Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Response To Growth Factor Cell Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Developmental Process Neuron Differentiation Cell Morphogenesis Involved In Differentiation Actin Filament Capping Cell Projection Organization Blood Coagulation Multicellular Organismal Development Hemostasis Negative Regulation Of Actin Filament Depolymerization Response To External Stimulus Cell Projection Morphogenesis Regulation Of Actin Filament Depolymerization Cell Part Morphogenesis Chemical Homeostasis System Development Negative Regulation Of Actin Filament Polymerization Homeostatic Process Cellular Chemical Homeostasis Negative Regulation Of Protein Polymerization Ion Homeostasis Regulation Of Body Fluid Levels Negative Regulation Of Protein Complex Disassembly Wound Healing Generation Of Neurons Hemopoiesis Regulation Of Protein Depolymerization Nervous System Development Neurogenesis Regulation Of Protein Complex Disassembly Response To Wounding Cellular Homeostasis Immune System Development
Tagcloud ?		aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytes spherocytosis splenectomy splenomegaly	antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Difference) ?		aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytosis splenectomy splenomegaly	antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spta1 sptb ugt1a1
Tagcloud (Intersection) ?		epb42 spherocytes