ATF1 and CAMK1

Number of citations: 0 (PubMedID 8384217)
Data Source: HPRD (in vitro)

		ATF1	CAMK1
Name		activating transcription factor 1	calcium/calmodulin dependent protein kinase I
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex	Nucleus Cytoplasm Cytosol Postsynaptic Density
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Response To Purine-containing Compound Response To Cobalt Ion Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly CAMP/PKA Signal Transduction	Protein Phosphorylation Nucleocytoplasmic Transport Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Intracellular Signal Transduction Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		CREB phosphorylation NGF-stimulated transcription NGF-stimulated transcription	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Pseudoephedrine	Fostamatinib
Diseases		Clear cell sarcoma of soft tissue	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Colorectal cancer ( 25990418 24737748 20972440 ) Colorectal cancer or advanced adenoma ( 30510241 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Male-pattern baldness ( 27182965 ) Mean arterial pressure ( 27618448 ) Multiple sclerosis ( 31604244 ) Spleen volume ( 34128465 ) Sudden cardiac arrest ( 21658281 ) Systolic blood pressure ( 30578418 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B DNMT3L EDF1 GABPA GABPB1 HNF1B JUN MAPKAPK2 MAPKAPK3 PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1	23 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 HUNK IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		466	8536
HPRD ID		00440	05412
Ensembl ID		ENSG00000123268	ENSG00000134072
Uniprot IDs		P18846	B0YIY3 Q14012
PDB IDs		Not available	4FG7 4FG8 4FG9 4FGB
GO Terms Enriched among Interactors		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Nucleoplasm Protein Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Kinase CK2 Complex Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Calmodulin Binding CAMP/PKA Signal Transduction Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Transferase Activity Phosphorylation Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Negative Regulation Of Biosynthetic Process Histone H3S28 Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding ATP Binding Chromatin Symbiont-mediated Disruption Of Host Cell PML Body	Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cyclin D1-CDK4 Complex Cell Cycle Phase Transition Response To Metal Ion Peptidyl-cysteine S-nitrosylase Activity Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Activity Positive Regulation Of Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Calcium-mediated Signaling Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Autophagy Positive Regulation Of Interleukin-1 Production Kinase Activity Regulation Of Metabolic Process Calcium-dependent Protein Binding Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Response To Lead Ion Calyx Of Held Regulation Of Neurotransmitter Uptake Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Regulation Of Locomotion Nucleus Regulation Of Cell Cycle Calcium/calmodulin-dependent Protein Kinase Activity Protein-containing Complex Regulation Of Interleukin-1 Production Nucleoplasm Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Mitotic Cell Cycle