ATF1 and EDF1

Number of citations of the paper that reports this interaction (PMID 10567391)
10

Data Source:
HPRD (in vitro)

		ATF1	EDF1
Gene Name		activating transcription factor 1	endothelial differentiation-related factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm ATF1-ATF4 Transcription Factor Complex	Intracellular Nucleus Transcription Factor TFIID Complex Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Calmodulin Binding Methyltransferase Activity Sequence-specific DNA Binding Poly(A) RNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Regulation Of Lipid Metabolic Process Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		CREB phosphorylation Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Colorectal cancer ( 20972440) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		20 interactors: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B EDF1 GABPA GABPB1 HNF1B JUN PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1	20 interactors: ATF1 ATF2 CALM1 CALM2 CALM3 CEBPA CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA TAF1 TBP UBE2I
Entrez ID		466	8721
HPRD ID		00440	09235
Ensembl ID		ENSG00000123268	ENSG00000107223
Uniprot IDs		P18846	O60869
PDB IDs			1X57
Enriched GO Terms of Interacting Partners?		Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Protein Phosphorylation Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Histone Acetylation Phosphorylation Response To Cytokine RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Axon Development Regulation Of Myeloid Cell Differentiation Gene Expression Chemotaxis Positive Regulation Of Histone Acetylation Negative Regulation Of Gene Expression Nervous System Development Cell Development Cellular Macromolecule Biosynthetic Process Axon Guidance Apoptotic Process Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Positive Regulation Of Protein Acetylation Programmed Cell Death Anatomical Structure Morphogenesis	Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Steroid Hormone Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Lipase Activity Response To Metal Ion Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Response To Lipid DNA-templated Transcription, Initiation Activation Of Phospholipase C Activity Response To Hormone Positive Regulation Of Phospholipase C Activity Gene Expression Response To Inorganic Substance Regulation Of Metabolic Process Organ Development Positive Regulation Of Phospholipase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Innate Immune Response Response To Organic Substance Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Activation Of Adenylate Cyclase Activity Nitrogen Compound Metabolic Process Regulation Of Phospholipase Activity RNA Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Immune Response Steroid Hormone Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of High Voltage-gated Calcium Channel Activity Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Organization Positive Regulation Of Adenylate Cyclase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Neurotrophin Signaling Pathway Regulation Of Immune System Process System Development Defense Response
Tagcloud ?		cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated	2e 3e 8e abstracts asco auc btg2 candidates cxcl10 cyp2d6 dataset datasets downloaded drg1 ega geo hoxb7 mapk1 mapt pgr platforms rfs rnaseq sabcs slc7a5 tamoxifen tcga tpm4 transcriptomic
Tagcloud (Difference) ?		cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated	2e 3e 8e abstracts asco auc btg2 candidates cxcl10 cyp2d6 dataset datasets downloaded drg1 ega geo hoxb7 mapk1 mapt pgr platforms rfs rnaseq sabcs slc7a5 tamoxifen tcga tpm4 transcriptomic
Tagcloud (Intersection) ?