SOX5 and CRX

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SOX5	CRX
Gene Name		SRY (sex determining region Y)-box 5	cone-rod homeobox
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Transcription Factor Complex	Nucleus Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Central Nervous System Neuron Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Oligodendrocyte Differentiation Cartilage Development Regulation Of Timing Of Neuron Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Visual Perception Circadian Rhythm Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Photoreceptor Cell Differentiation Response To Stimulus Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS		AIDS ( 19754311) Non-obstructive azoospermia ( 22197933) PR interval ( 20062060) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		26 interactors: AES APP ARID5A CBX8 CDC23 CDC25A CDK6 CRX FAM46B FTH1 KAT5 KIFC3 LMO1 LMO2 MED27 MORN3 PRR20A RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TTC1 UQCRFS1 ZNF581	44 interactors: ABI2 AES ATG12 ATXN7 BANF1 C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 EIF5A EP300 GCM2 GUCD1 IPO13 KAT2A KIAA0141 KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PARK2 PDC PID1 PPP1R16B PRKAB2 PSMB10 QRICH1 RAX2 RBFOX1 ROR2 SFI1 SOX5 STK16 SZT2 UBXN2B
Entrez ID		6660	1406
HPRD ID		18086	03748
Ensembl ID		ENSG00000134532	ENSG00000105392
Uniprot IDs		P35711 T2CYZ2	O43186
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Osteoblast Fate Commitment Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cartilage Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process BMP Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Connective Tissue Development Transcription From RNA Polymerase II Promoter Metabolic Process Skeletal System Development Negative Regulation Of Biosynthetic Process Organ Development Cellular Response To BMP Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Rhodopsin Gene Expression N-terminal Peptidyl-lysine Acetylation Regulation Of Rhodopsin Gene Expression Transcription, DNA-templated Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitochondrial Fusion Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Autophagy N-terminal Protein Amino Acid Acetylation Nuclear Envelope Reassembly Cellular Response To Stimulus Response To Stimulus Negative Regulation Of Wnt Signaling Pathway Cellular Metabolic Process Somitogenesis Cellular Nitrogen Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone Deubiquitination Neurological System Process Somite Development Cellular Response To Stress Regulation Of Type I Interferon Production Peptidyl-amino Acid Modification Peptidyl-lysine Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		aberrantly abrogated alcian atdc5 blue box chondrocyte chondrogenesis chondrogenic clonal delayed determining differentiating diminish drastic evidenced fate hypertrophic l lineage mobility osteoarthritic overexpressing progress proteoglycan retroviral runx2 unaltered	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Difference) ?		aberrantly abrogated alcian atdc5 blue box chondrocyte chondrogenesis chondrogenic clonal delayed determining differentiating diminish drastic evidenced fate hypertrophic l lineage mobility osteoarthritic overexpressing progress proteoglycan retroviral runx2 unaltered	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Intersection) ?