SOX5 and UQCRFS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SOX5	UQCRFS1
Description		SRY-box transcription factor 5	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Respiratory Chain Complex III
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Protein Binding Quinol-cytochrome-c Reductase Activity Oxidoreductase Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Cartilage Development Asymmetric Neuroblast Division Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Respiratory Electron Transport Chain Mitochondrial Respiratory Chain Complex III Assembly Proton Transmembrane Transport
Pathways			Complex III assembly Complex III assembly Complex III assembly Complex III assembly Complex III assembly Respiratory electron transport Complex III assembly Complex III assembly Complex III assembly Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) AIDS ( 19754311) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 29325848) Body mass index ( 25673413) Chronic back pain ( 30261039) Chronotype ( 30696823) Creatinine levels ( 29403010) Depression ( 29700475) Glomerular filtration rate ( 29403010) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Juvenile osteochondritis dissecans ( 26422391) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mortality in sepsis ( 27639821) Multisite chronic pain ( 33830993) Non-obstructive azoospermia ( 22197933) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Pelvic organ prolapse (moderate/severe) ( 26545240) PR interval ( 30046033 20062060 29127183 32439900) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656) Systemic sclerosis ( 21779181) Systolic blood pressure ( 30224653) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Disease progression in age-related macular degeneration ( 29346644) Methadone dose in opioid dependence ( 28115739) Stroke ( 32693751)
Interacting Genes		42 interacting genes: APP ARID5A BIRC7 CAMK2A CBX8 CDC23 CDC25A CDK6 CRX FOXP1 FOXP2 FOXP4 FTH1 FXR1 HNF1B KAT5 KIFC3 LMO1 LMO2 MAGED1 MED27 MORN3 MSX2 NFIC NFIX PIAS2 PRR20A RNF4 RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TENT5B TEX11 TRAF2 TTC1 UBE2I UQCRFS1 ZBTB26 ZNF581	4 interacting genes: CYC1 HTR6 RELB SOX5
Entrez ID		6660	7386
HPRD ID		18086	01874
Ensembl ID		ENSG00000134532	ENSG00000169021
Uniprot IDs		F5H0I3 P35711 T2CYZ2	P47985
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Chromatin Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Heteromeric SMAD Protein Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Nucleoplasm Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Mesonephric Tubule Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mesonephric Epithelium Development I-SMAD Binding Cardiac Conduction System Development Stem Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Transcription Factor Binding Osteoblast Fate Commitment Striated Muscle Tissue Development Identical Protein Binding Epithelium Development Kidney Epithelium Development Positive Regulation Of RNA Metabolic Process Mitotic Cell Cycle Phase Transition Muscle Tissue Development
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