SOX4 and EDF1

Number of citations of the paper that reports this interaction (PubMedID 25969425)
0

Data Source:
BioGRID (two hybrid)

		SOX4	EDF1
Description		SRY-box transcription factor 4	endothelial differentiation related factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	TFIID-class Transcription Factor Complex Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Calmodulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Gene Expression Glial Cell Proliferation Spinal Cord Development Glial Cell Development Neuron Differentiation T Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Camera-type Eye Morphogenesis Protein Stabilization Ventricular Septum Morphogenesis Mesenchyme Development Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Lipid Metabolic Process Cell Differentiation Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophilic esophagitis ( 34506852) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	23 interacting genes: ATF1 ATF2 CALM1 CALM2 CALM3 CDC42 CEBPA CFTR CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA SOX4 TAF1 TBP UBE2I
Entrez ID		6659	8721
HPRD ID		01695	09235
Ensembl ID		ENSG00000124766	ENSG00000107223
Uniprot IDs		Q06945	O60869
PDB IDs			1X57 6ZVH
Enriched GO Terms of Interacting Partners?		Striated Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Development Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Muscle Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Ras Protein Signal Transduction Positive Regulation Of Developmental Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Positive Regulation Of Catalytic Activity Cell Differentiation Regulation Of Developmental Process Intracellular Signaling Cassette Positive Regulation Of Cell Differentiation Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Cell Cycle Process Negative Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of Cell Growth Regulation Of Multicellular Organismal Process Negative Regulation Of Transcription By RNA Polymerase II Forebrain Astrocyte Development Schwann Cell Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Intracellular Signal Transduction Myotube Differentiation Regulation Of MiRNA Transcription Rac Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Development Regulation Of Metabolic Process	RNA Polymerase II Transcription Regulator Complex Chromatin MRNA Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Intracellular Signaling Cassette Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcineurin-mediated Signaling Positive Regulation Of RNA Metabolic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Transcription Coregulator Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Double-stranded DNA Binding Developmental Process Neural Nucleus Development Transcription Regulator Complex Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Leukocyte Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Myeloid Leukocyte Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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