SOX4 and MINPP1

Number of citations of the paper that reports this interaction (PubMedID 25969425)
0

Data Source:
BioGRID (two hybrid)

		SOX4	MINPP1
Description		SRY-box transcription factor 4	multiple inositol-polyphosphate phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	Acid Phosphatase Activity Inositol Hexakisphosphate Phosphatase Activity Protein Binding Inositol Hexakisphosphate 4-phosphatase Activity Inositol Hexakisphosphate 3-phosphatase Activity Inositol Bisphosphate Phosphatase Activity Hydrolase Activity Phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Inositol-1,4,5,6-tetrakisphosphate 6-phosphatase Activity Bisphosphoglycerate 3-phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol Phosphate Phosphatase Activity Inositol Pentakisphosphate Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Gene Expression Glial Cell Proliferation Spinal Cord Development Glial Cell Development Neuron Differentiation T Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Camera-type Eye Morphogenesis Protein Stabilization Ventricular Septum Morphogenesis Mesenchyme Development Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Ossification Intracellular Monoatomic Cation Homeostasis Bone Mineralization Inositol Phosphate Metabolic Process
Pathways		Deactivation of the beta-catenin transactivating complex	Synthesis of IPs in the ER lumen
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophilic esophagitis ( 34506852) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Blood protein levels ( 30072576) Forehead morphology ( 29921221) Longevity ( 20304771) Pursuit maintenance gain ( 29064472)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	5 interacting genes: ACTA1 OGT SOX4 SRF UBQLN2
Entrez ID		6659	9562
HPRD ID		01695	05652
Ensembl ID		ENSG00000124766	ENSG00000107789
Uniprot IDs		Q06945	Q9UNW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Striated Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Development Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Muscle Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Ras Protein Signal Transduction Positive Regulation Of Developmental Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Positive Regulation Of Catalytic Activity Cell Differentiation Regulation Of Developmental Process Intracellular Signaling Cassette Positive Regulation Of Cell Differentiation Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Cell Cycle Process Negative Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of Cell Growth Regulation Of Multicellular Organismal Process Negative Regulation Of Transcription By RNA Polymerase II Forebrain Astrocyte Development Schwann Cell Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Intracellular Signal Transduction Myotube Differentiation Regulation Of MiRNA Transcription Rac Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Development Regulation Of Metabolic Process	Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Intracellular Glucose Homeostasis Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose Response To Glucose Response To Monosaccharide Response To Carbohydrate Carbohydrate Homeostasis Glucose Homeostasis Cell Development Cellular Response To Nutrient Positive Regulation Of Macromolecule Metabolic Process Intracellular Chemical Homeostasis Chromatin DNA Binding Serum Response Element Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Metabolic Process Hematopoietic Progenitor Cell Differentiation Cellular Homeostasis Bronchus Cartilage Development Lung Smooth Muscle Development Negative Regulation Of G Protein-coupled Receptor Internalization Organelle Assembly Response To Nutrient Protein O-acetylglucosaminyltransferase Activity Ascending Aorta Morphogenesis Pro-B Cell Differentiation Chemical Homeostasis Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Hemopoiesis Negative Regulation Of Clathrin-dependent Endocytosis Cellular Response To Oxygen-containing Compound Mesenchyme Migration Atrial Septum Primum Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Skeletal Muscle Thin Filament Assembly Tangential Migration From The Subventricular Zone To The Olfactory Bulb Non-canonical Inflammasome Complex Assembly Noradrenergic Neuron Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Nutrient Levels Actin Filament Organization Mitral Valve Morphogenesis
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