SOX4 and RP1L1

Number of citations of the paper that reports this interaction (PubMedID 25969425)
0

Data Source:
BioGRID (two hybrid)

		SOX4	RP1L1
Description		SRY-box transcription factor 4	RP1 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Photoreceptor Outer Segment Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Photoreceptor Connecting Cilium Cell Projection
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Gene Expression Glial Cell Proliferation Spinal Cord Development Glial Cell Development Neuron Differentiation T Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Camera-type Eye Morphogenesis Protein Stabilization Ventricular Septum Morphogenesis Mesenchyme Development Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Visual Perception Cell Projection Organization Axoneme Assembly Intracellular Signal Transduction Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Development Photoreceptor Cell Maintenance Retina Development In Camera-type Eye
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases			Occult macular dystrophy (OMD)
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophilic esophagitis ( 34506852) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	A body shape index ( 34021172) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Heart rate response to exercise ( 29769521) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 30275531) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Osteoarthrosis (time to event) ( 32589924) Processed meat consumption ( 32066663) Red cell distribution width ( 32888494) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	1 interacting genes: SOX4
Entrez ID		6659	94137
HPRD ID		01695	10546
Ensembl ID		ENSG00000124766	ENSG00000183638
Uniprot IDs		Q06945	Q8IWN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Striated Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Development Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Muscle Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Ras Protein Signal Transduction Positive Regulation Of Developmental Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Positive Regulation Of Catalytic Activity Cell Differentiation Regulation Of Developmental Process Intracellular Signaling Cassette Positive Regulation Of Cell Differentiation Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Cell Cycle Process Negative Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of Cell Growth Regulation Of Multicellular Organismal Process Negative Regulation Of Transcription By RNA Polymerase II Forebrain Astrocyte Development Schwann Cell Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Intracellular Signal Transduction Myotube Differentiation Regulation Of MiRNA Transcription Rac Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Development Regulation Of Metabolic Process	Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Lymphoid Progenitor Cell Differentiation Atrial Septum Primum Morphogenesis Cardiac Right Ventricle Morphogenesis Ascending Aorta Morphogenesis Positive Regulation Of Protein Localization Pro-B Cell Differentiation Regulation Of Protein Stability Regulation Of Gamma-delta T Cell Differentiation Noradrenergic Neuron Differentiation Mitral Valve Morphogenesis Protein Localization To Chromosome, Telomeric Region Telomerase Inhibitor Activity Regulation Of Protein Localization To Nucleolus Protein Localization To Nucleolus Positive Regulation Of Protein Localization To Nucleolus Kidney Morphogenesis Endocrine Pancreas Development Sympathetic Nervous System Development Atrial Septum Morphogenesis Spinal Cord Development Hematopoietic Stem Cell Homeostasis Atrioventricular Valve Morphogenesis Camera-type Eye Morphogenesis Glial Cell Proliferation Cardiac Ventricle Morphogenesis Regulation Of Protein Localization Negative Regulation Of Myoblast Differentiation Telomerase RNA Binding Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening MiRNA Binding Neuroepithelial Cell Differentiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Maintenance Ventricular Septum Morphogenesis Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Myoblast Differentiation Mitotic Metaphase Chromosome Alignment Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Glucose Stimulus Cardiac Septum Morphogenesis Somatic Stem Cell Population Maintenance
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