SOX4 and IGF1

Number of citations of the paper that reports this interaction (PubMedID 25969425)
0

Data Source:
BioGRID (two hybrid)

		SOX4	IGF1
Description		SRY-box transcription factor 4	insulin like growth factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex Secretory Granule Platelet Alpha Granule Lumen Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin-like Growth Factor Ternary Complex Exocytic Vesicle Postsynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Gene Expression Glial Cell Proliferation Spinal Cord Development Glial Cell Development Neuron Differentiation T Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Camera-type Eye Morphogenesis Protein Stabilization Ventricular Septum Morphogenesis Mesenchyme Development Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Skeletal System Development Osteoblast Differentiation Cell Activation Epithelial To Mesenchymal Transition Blood Vessel Remodeling Signal Transduction Ras Protein Signal Transduction Nervous System Development Muscle Organ Development Circadian Rhythm Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Heat Glycolate Metabolic Process Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Differentiation Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Proteoglycan Biosynthetic Process Lung Development Positive Regulation Of Cell Migration Androgen Receptor Signaling Pathway Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Myelination Activation Of Protein Kinase B Activity Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organism Growth Bone Mineralization Involved In Bone Maturation Wound Healing Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Nitric Oxide Biosynthetic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Protein Stabilization Regulation Of Protein Metabolic Process Myoblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Oocyte Development Growth Hormone Receptor Signaling Pathway Lung Vasculature Development Lung Lobe Morphogenesis Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Surface Receptor Signaling Pathway Via STAT Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Trophectodermal Cell Proliferation Cellular Response To Amyloid-beta Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Myoblast Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Deactivation of the beta-catenin transactivating complex	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin
Drugs			N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Malignant pleural mesothelioma
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophilic esophagitis ( 34506852) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Birth weight ( 27680694 31043758) Brain morphology (MOSTest) ( 32665545) Cortical volume ( 32963231) Dental caries (decayed and filled deciduous teeth) ( 31533690) Fasting blood insulin ( 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) FEV1 ( 30804560) Height ( 34270706 19893584 31562340 31217584 20189936 25429064) Hip circumference adjusted for BMI ( 34021172) Homeostasis model assessment of insulin resistance ( 20081858) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Lung function (FVC) ( 30804560) Mammographic density (dense area) ( 25342443) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Response to quetiapine in schizophrenia ( 29503163) Systolic blood pressure ( 30224653) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	22 interacting genes: BANP CCN3 CCN5 CTSB E2F1 ENKD1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 MESD MKRN3 SOX4 TCEANC TF
Entrez ID		6659	3479
HPRD ID		01695	00936
Ensembl ID		ENSG00000124766	ENSG00000017427
Uniprot IDs		Q06945	P05019 Q13429 Q59GC5 Q5U743
PDB IDs			1B9G 1BQT 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI 4XSS 5U8Q 6FF3 6PYH 6RVA 7S0Q 7WRQ 7YRR 8EYR 8X06 8X2M 8XJS 8XK1 8XKM 8XKR
Enriched GO Terms of Interacting Partners?		Striated Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Development Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Muscle Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Ras Protein Signal Transduction Positive Regulation Of Developmental Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Positive Regulation Of Catalytic Activity Cell Differentiation Regulation Of Developmental Process Intracellular Signaling Cassette Positive Regulation Of Cell Differentiation Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Cell Cycle Process Negative Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of Cell Growth Regulation Of Multicellular Organismal Process Negative Regulation Of Transcription By RNA Polymerase II Forebrain Astrocyte Development Schwann Cell Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Intracellular Signal Transduction Myotube Differentiation Regulation Of MiRNA Transcription Rac Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Development Regulation Of Metabolic Process	Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Extracellular Region Insulin-like Growth Factor Ternary Complex Type B Pancreatic Cell Proliferation Extracellular Space Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Lumen Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Binding Protein Complex Negative Regulation Of Signal Transduction Fibronectin Binding Regulation Of Growth Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Signal Transduction Insulin Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Epithelial Cell Proliferation Insulin Receptor Signaling Pathway Signaling Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Amyloid-beta Clearance Hematopoietic Stem Cell Homeostasis Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Beta-endorphin Binding Negative Regulation Of Skeletal Muscle Hypertrophy Insulin-like Growth Factor Binary Complex Response To Hormone Regulation Of MAPK Cascade Positive Regulation Of Myoblast Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Carbohydrate Homeostasis Glucose Homeostasis
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