EDF1 and NR5A2

Number of citations of the paper that reports this interaction (PMID 12040021)
10

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EDF1	NR5A2
Gene Name		endothelial differentiation-related factor 1	nuclear receptor subfamily 5, group A, member 2
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Transcription Factor TFIID Complex Nucleolus Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Calmodulin Binding Methyltransferase Activity Sequence-specific DNA Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Regulation Of Lipid Metabolic Process Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Bile Acid Metabolic Process Embryo Development Gene Expression Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Regulation Of Cell Proliferation Homeostatic Process Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Pancreatic cancer ( 20101243)
Protein-Protein Interactions		20 interactors: ATF1 ATF2 CALM1 CALM2 CALM3 CEBPA CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA TAF1 TBP UBE2I	19 interactors: ALB BCKDK COPS5 EDF1 FTH1 NCOA1 NCOA3 NPPA NR0B2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SRC UBE2I
Entrez ID		8721	2494
HPRD ID		09235	06830
Ensembl ID		ENSG00000107223	ENSG00000116833
Uniprot IDs		O60869	B4E2P3 F1D8R9 O00482
PDB IDs		1X57	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Steroid Hormone Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Lipase Activity Response To Metal Ion Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Response To Lipid DNA-templated Transcription, Initiation Activation Of Phospholipase C Activity Response To Hormone Positive Regulation Of Phospholipase C Activity Gene Expression Response To Inorganic Substance Regulation Of Metabolic Process Organ Development Positive Regulation Of Phospholipase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Innate Immune Response Response To Organic Substance Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Activation Of Adenylate Cyclase Activity Nitrogen Compound Metabolic Process Regulation Of Phospholipase Activity RNA Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Immune Response Steroid Hormone Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of High Voltage-gated Calcium Channel Activity Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Organization Positive Regulation Of Adenylate Cyclase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Neurotrophin Signaling Pathway Regulation Of Immune System Process System Development Defense Response	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Metabolic Process Metabolic Process Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Labyrinthine Layer Morphogenesis Positive Regulation Of Organelle Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Placenta Morphogenesis Gland Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Response To Nutrient Levels Mammary Gland Development Anatomical Structure Development Negative Regulation Of Gene Expression Response To Extracellular Stimulus Negative Regulation Of Biosynthetic Process
Tagcloud ?		2e 3e 8e abstracts asco auc btg2 candidates cxcl10 cyp2d6 dataset datasets downloaded drg1 ega geo hoxb7 mapk1 mapt pgr platforms rfs rnaseq sabcs slc7a5 tamoxifen tcga tpm4 transcriptomic	4f 6f boosts copyright dn endogenously epiblast episcs feeder impedes ipscs klf4 lrh1 mef mefs n2b27 oct4 pluripotency pluripotent primed rarg reprogram reprogramming reprograms reserved rights sox2 supplementing synthesised
Tagcloud (Difference) ?		2e 3e 8e abstracts asco auc btg2 candidates cxcl10 cyp2d6 dataset datasets downloaded drg1 ega geo hoxb7 mapk1 mapt pgr platforms rfs rnaseq sabcs slc7a5 tamoxifen tcga tpm4 transcriptomic	4f 6f boosts copyright dn endogenously epiblast episcs feeder impedes ipscs klf4 lrh1 mef mefs n2b27 oct4 pluripotency pluripotent primed rarg reprogram reprogramming reprograms reserved rights sox2 supplementing synthesised
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