EDF1 and ATF2

Number of citations of the paper that reports this interaction (PubMedID 10567391)
0

Data Source:
HPRD (in vitro)

		EDF1	ATF2
Description		endothelial differentiation related factor 1	activating transcription factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Site Of Double-strand Break RNA Polymerase II Transcription Regulator Complex H4 Histone Acetyltransferase Complex
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Calmodulin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Sequence-specific DNA Binding Histone H2B Acetyltransferase Activity Metal Ion Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Lipid Metabolic Process Cell Differentiation Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development NK T Cell Differentiation Liver Development Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Brainstem Development Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Lipid Metabolic Process Apoptotic Process Response To Osmotic Stress DNA Damage Response Vacuole Organization JNK Cascade Heart Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-threonine Phosphorylation Abducens Nucleus Development Hypoglossal Nucleus Development Facial Nucleus Development BMP Signaling Pathway Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Oxidative Stress P38MAPK Cascade MRNA Transcription By RNA Polymerase II Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Neurofilament Cytoskeleton Organization Detection Of Cell Density Adipose Tissue Development Cellular Response To Anisomycin Motor Neuron Apoptotic Process Hepatocyte Apoptotic Process Cellular Response To Virus Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Development Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Cellular Response To Leucine Starvation
Pathways			Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Pseudoephedrine
Diseases
GWAS			Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: ATF1 ATF2 CALM1 CALM2 CALM3 CDC42 CEBPA CFTR CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA SOX4 TAF1 TBP UBE2I	61 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FAM13A-AS1 FOS GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I USP14 UTF1 XPO1 YY1
Entrez ID		8721	1386
HPRD ID		09235	00443
Ensembl ID		ENSG00000107223	ENSG00000115966
Uniprot IDs		O60869	A4D7V5 P15336
PDB IDs		1X57 6ZVH	1BHI 1T2K 4H36 6ZQS 6ZR5
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Chromatin MRNA Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Intracellular Signaling Cassette Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcineurin-mediated Signaling Positive Regulation Of RNA Metabolic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Transcription Coregulator Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Double-stranded DNA Binding Developmental Process Neural Nucleus Development Transcription Regulator Complex Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Leukocyte Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Myeloid Leukocyte Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Intracellular Signaling Cassette Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity DNA Binding Response To Stress Transcription Cis-regulatory Region Binding Integrated Stress Response Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MAPK Cascade RNA Polymerase II-specific DNA-binding Transcription Factor Binding Macromolecule Metabolic Process DNA Damage Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Senescence Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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