EDF1 and ATF1

Number of citations: 0 (PubMedID 10567391)
Data Source: HPRD (in vitro)

		EDF1	ATF1
Name		endothelial differentiation related factor 1	activating transcription factor 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Calmodulin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Lipid Metabolic Process Cell Differentiation Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Response To Purine-containing Compound Response To Cobalt Ion Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly CAMP/PKA Signal Transduction
Pathways		None	CREB phosphorylation NGF-stimulated transcription NGF-stimulated transcription
Drugs		None	Pseudoephedrine
Diseases		None	Clear cell sarcoma of soft tissue
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Colorectal cancer ( 25990418 24737748 20972440 ) Colorectal cancer or advanced adenoma ( 30510241 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Male-pattern baldness ( 27182965 ) Mean arterial pressure ( 27618448 ) Multiple sclerosis ( 31604244 ) Spleen volume ( 34128465 ) Sudden cardiac arrest ( 21658281 ) Systolic blood pressure ( 30578418 )
Interacting Genes		23 interacting genes: ATF1 ATF2 CALM1 CALM2 CALM3 CDC42 CEBPA CFTR CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA SOX4 TAF1 TBP UBE2I	23 interacting genes: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B DNMT3L EDF1 GABPA GABPB1 HNF1B JUN MAPKAPK2 MAPKAPK3 PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		8721	466
HPRD ID		09235	00440
Ensembl ID		ENSG00000107223	ENSG00000123268
Uniprot IDs		O60869	P18846
PDB IDs		1X57 6ZVH	Not available
GO Terms Enriched among Interactors		RNA Polymerase II Transcription Regulator Complex Chromatin MRNA Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Intracellular Signaling Cassette Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcineurin-mediated Signaling Positive Regulation Of RNA Metabolic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Transcription Coregulator Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Double-stranded DNA Binding Developmental Process Neural Nucleus Development Transcription Regulator Complex Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Leukocyte Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Myeloid Leukocyte Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Nucleoplasm Protein Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Kinase CK2 Complex Kinase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Calmodulin Binding CAMP/PKA Signal Transduction Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Transferase Activity Phosphorylation Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Negative Regulation Of Biosynthetic Process Histone H3S28 Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding ATP Binding Chromatin Symbiont-mediated Disruption Of Host Cell PML Body