SOX4 and PLD3

Number of citations of the paper that reports this interaction (PubMedID 25969425)
0

Data Source:
BioGRID (two hybrid)

		SOX4	PLD3
Description		SRY-box transcription factor 4	phospholipase D family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endosome Membrane Endomembrane System Membrane Early Endosome Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Protein Binding Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Gene Expression Glial Cell Proliferation Spinal Cord Development Glial Cell Development Neuron Differentiation T Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Camera-type Eye Morphogenesis Protein Stabilization Ventricular Septum Morphogenesis Mesenchyme Development Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Immune System Process DNA Metabolic Process Lipid Metabolic Process Inflammatory Response Myotube Differentiation Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Deactivation of the beta-catenin transactivating complex	Synthesis of PG Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophilic esophagitis ( 34506852) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	13 interacting genes: ANXA7 BCL2L1 CNIH3 GPR35 HGS NFKB1 OGT OPRM1 SMCO4 SOX4 SPP1 STK11 TK1
Entrez ID		6659	23646
HPRD ID		01695	07148
Ensembl ID		ENSG00000124766	ENSG00000105223
Uniprot IDs		Q06945	Q8IV08
PDB IDs			8Q1K 8Q1X 8S86 8V5T
Enriched GO Terms of Interacting Partners?		Striated Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Development Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Muscle Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Ras Protein Signal Transduction Positive Regulation Of Developmental Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Positive Regulation Of Catalytic Activity Cell Differentiation Regulation Of Developmental Process Intracellular Signaling Cassette Positive Regulation Of Cell Differentiation Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Cell Cycle Process Negative Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of Cell Growth Regulation Of Multicellular Organismal Process Negative Regulation Of Transcription By RNA Polymerase II Forebrain Astrocyte Development Schwann Cell Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Intracellular Signal Transduction Myotube Differentiation Regulation Of MiRNA Transcription Rac Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Development Regulation Of Metabolic Process	Regulation Of Transport Autophagy Negative Regulation Of Developmental Process Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Process Regulation Of Neurotransmitter Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Alkaloid Mitochondrial Membrane Regulation Of Signal Transduction Apoptotic Process In Bone Marrow Cell Positive Regulation Of Transport Regulation Of Signaling Receptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macroautophagy Vacuole-isolation Membrane Contact Site Response To Ketone Regulation Of Protein Localization Negative Regulation Of Growth Synapse Regulation Of Cellular Response To Stress Protein Localization To Lysosome Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Reproductive Process Regulation Of Canonical Wnt Signaling Pathway NF-kappaB P50/p65 Complex Regulation Of Secretion By Cell Cellular Response To Glucose Stimulus Positive Regulation Of Estradiol Secretion Thymidine Kinase Activity C-terminal Protein Lipidation Regulation Of Growth Mitochondrion Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Positive Regulation Of Lipid Transport Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex
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