ALX4 and HOXB13

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ALX4	HOXB13
Gene Name		ALX homeobox 4	homeobox B13
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	Sequence-specific DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Embryonic Skeletal System Morphogenesis Palate Development	Angiogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Epidermis Development Response To Wounding Response To Testosterone Regulation Of Growth Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		12 interactors: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2	7 interactors: ALX4 ELK1 HOXD4 IRF4 MEIS1 POU2F1 ZNF490
Entrez ID		60529	10481
HPRD ID		05661	05210
Ensembl ID		ENSG00000052850	ENSG00000159184
Uniprot IDs		Q9H161	Q4KR72 Q92826
PDB IDs		2M0C	2CRA
Enriched GO Terms of Interacting Partners?		Organ Development Organ Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process System Development Embryonic Organ Development Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Multicellular Organismal Development Embryonic Organ Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Anatomical Structure Morphogenesis Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Tissue Development Embryonic Skeletal System Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Tube Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Mesenchyme Development Gland Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Stem Cell Development	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Lens Morphogenesis In Camera-type Eye Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Regulation Of Metabolic Process Lens Development In Camera-type Eye Cellular Response To Testosterone Stimulus Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Camera-type Eye Morphogenesis Developmental Process Eye Morphogenesis Positive Regulation Of Metabolic Process T-helper 17 Cell Lineage Commitment Olfactory Placode Formation T-helper 17 Cell Differentiation Myeloid Cell Differentiation Organ Morphogenesis Cellular Metabolic Process Lens Induction In Camera-type Eye Cell Fate Commitment T-helper Cell Lineage Commitment Positive Regulation Of Interleukin-2 Biosynthetic Process Multicellular Organismal Development Camera-type Eye Development Megakaryocyte Development
Tagcloud ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	1x10 27x10 assessing carrier country explains familial g84e genotyped geographic gleason hereditary largest missense multiplicatively nccn polygenic prca protect psa rs138213197 snp snps stratifying tnm uk ukgpcs variant varies
Tagcloud (Difference) ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	1x10 27x10 assessing carrier country explains familial g84e genotyped geographic gleason hereditary largest missense multiplicatively nccn polygenic prca protect psa rs138213197 snp snps stratifying tnm uk ukgpcs variant varies
Tagcloud (Intersection) ?