ALX4 and HOXD3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ALX4	HOXD3
Gene Name		ALX homeobox 4	homeobox D3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Embryonic Skeletal System Morphogenesis Palate Development	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Thyroid Gland Development Positive Regulation Of Neuron Differentiation Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways
Drugs
Diseases
GWAS			Ovarian cancer ( 20852632)
Protein-Protein Interactions		12 interactors: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2	4 interactors: ALX4 DDB1 HMGB1 HOXA1
Entrez ID		60529	3232
HPRD ID		05661	00863
Ensembl ID		ENSG00000052850	ENSG00000128652
Uniprot IDs		Q9H161	P31249
PDB IDs		2M0C
Enriched GO Terms of Interacting Partners?		Organ Development Organ Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process System Development Embryonic Organ Development Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Multicellular Organismal Development Embryonic Organ Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Anatomical Structure Morphogenesis Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Tissue Development Embryonic Skeletal System Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Tube Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Mesenchyme Development Gland Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Stem Cell Development	Optokinetic Behavior Abducens Nerve Formation Negative Regulation Of Apoptotic Cell Clearance Embryonic Skeletal System Morphogenesis DNA Catabolic Process Embryonic Skeletal System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Facial Nucleus Development Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhombomere 4 Development Semicircular Canal Formation Negative Regulation Of DNA-templated Transcription, Initiation Rhombomere 3 Development Rhombomere 5 Development Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Base-excision Repair, DNA Ligation Skeletal System Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death UV-damage Excision Repair Embryonic Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Viral Release From Host Cell Embryonic Neurocranium Morphogenesis Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Outer Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Semicircular Canal Morphogenesis Rhombomere Development Regulation Of Apoptotic Cell Clearance Facial Nerve Structural Organization Pons Development Histone H2A Monoubiquitination Negative Regulation Of Phagocytosis Cellular Nitrogen Compound Metabolic Process Facial Nerve Morphogenesis Response To Radiation Aromatic Compound Catabolic Process DNA Ligation Dendritic Cell Chemotaxis
Tagcloud ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	alphavbeta3 characterizes cooperating cyclin d1a d1b damaged ectopic enhance exploration holds indicates introduced invasive invasiveness makes mcf mediator metastatic modulate notably oncogenic poorly promotes released reveal splice toll variant
Tagcloud (Difference) ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	alphavbeta3 characterizes cooperating cyclin d1a d1b damaged ectopic enhance exploration holds indicates introduced invasive invasiveness makes mcf mediator metastatic modulate notably oncogenic poorly promotes released reveal splice toll variant
Tagcloud (Intersection) ?