ALX4 and HOXA3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ALX4	HOXA3
Gene Name		ALX homeobox 4	homeobox A3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding HMG Box Domain Binding
	Biological Process	Skeletal System Development Hair Follicle Development Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Embryonic Skeletal System Morphogenesis Palate Development	Angiogenesis Blood Vessel Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Specification Of Organ Position Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Thymus Development Organ Formation Embryonic Skeletal System Morphogenesis Cartilage Development Parathyroid Gland Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2	9 interactors: ALX4 ARPC3 POT1 PWP1 SEC23B SOX10 TERF1 TINF2 ZDHHC17
Entrez ID		60529	3200
HPRD ID		05661	00842
Ensembl ID		ENSG00000052850	ENSG00000105997
Uniprot IDs		Q9H161	A4D182 B3KPN8 O43365
PDB IDs		2M0C
Enriched GO Terms of Interacting Partners?		Organ Development Organ Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process System Development Embryonic Organ Development Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Multicellular Organismal Development Embryonic Organ Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Anatomical Structure Morphogenesis Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Tissue Development Embryonic Skeletal System Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Tube Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Mesenchyme Development Gland Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Stem Cell Development	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Telomere Maintenance Telomere Assembly Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Positive Regulation Of Organelle Organization Regulation Of DNA Replication Regulation Of Telomerase Activity RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Organelle Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein ADP-ribosylation Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Protein Polymerization Negative Regulation Of Biosynthetic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Digestive Tract Development Positive Regulation Of DNA Metabolic Process Digestive System Development Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Positive Regulation Of Protein Complex Assembly Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Helicase Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cytoskeleton Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication
Tagcloud ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	a11 a13 a7 a9 bases ccctc cluster colinearity controller ctcf facilitates h3k27me3 hoxa9 locus looping loops organized polycomb positional prc2 repressive sequentially silencing silent stabilization trimethylated vertebrate
Tagcloud (Difference) ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	a11 a13 a7 a9 bases ccctc cluster colinearity controller ctcf facilitates h3k27me3 hoxa9 locus looping loops organized polycomb positional prc2 repressive sequentially silencing silent stabilization trimethylated vertebrate
Tagcloud (Intersection) ?