ALX4 and FOXA3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ALX4	FOXA3
Gene Name		ALX homeobox 4	forkhead box A3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Embryonic Skeletal System Morphogenesis Palate Development	Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Spermatogenesis Cellular Response To Starvation Chromatin Modification Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2	5 interactors: ALX4 HMGB1 PPARA TLE1 TLE2
Entrez ID		60529	3171
HPRD ID		05661	03802
Ensembl ID		ENSG00000052850	ENSG00000170608
Uniprot IDs		Q9H161	P55318
PDB IDs		2M0C	1VTN
Enriched GO Terms of Interacting Partners?		Organ Development Organ Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process System Development Embryonic Organ Development Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Multicellular Organismal Development Embryonic Organ Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Anatomical Structure Morphogenesis Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Tissue Development Embryonic Skeletal System Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Tube Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Mesenchyme Development Gland Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Stem Cell Development	Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Wnt Signaling Pathway Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Regulation Of Binding Organ Development Negative Regulation Of Receptor Biosynthetic Process Epidermis Development Wnt Signaling Pathway Behavioral Response To Nicotine Enamel Mineralization RNA Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage
Tagcloud ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53	cancerous cb chinese counterparts csf1r ctnnb1 drastic functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes onecut1 option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid
Tagcloud (Difference) ?		associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 screen shh sonic strengthening subtype tended tgif2 transposon trp53	cancerous cb chinese counterparts csf1r ctnnb1 drastic functionally genotyped hbv hcc hot jak1 livers mafg nras onecut1 option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid
Tagcloud (Intersection) ?		oncogenes