SNX2 and SNX5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SNX2	SNX5
Gene Name		sorting nexin 2	sorting nexin 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome	Ruffle Phagocytic Cup Cytoplasmic Vesicle Membrane Retromer Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Macropinocytic Cup Tubular Endosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Dynactin Binding Phosphatidylinositol Binding
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle Organization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Protein Oligomerization Lamellipodium Morphogenesis	Intracellular Protein Transport Pinocytosis Vesicle Organization Retrograde Transport, Endosome To Golgi
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202	14 interactors: APPBP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESDC2 MIB1 PFDN1 PRKRA SNX2
Entrez ID		6643	27131
HPRD ID		09332	10439
Ensembl ID		ENSG00000205302	ENSG00000089006
Uniprot IDs		B4DEK4 B7Z408 O60749	Q6P5V6 Q9Y5X3
PDB IDs			1SYS
Enriched GO Terms of Interacting Partners?		Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Migration Positive Regulation Of Locomotion Protein Phosphorylation Regulation Of Cell Motility Phosphorylation Regulation Of Signaling Retina Vasculature Development In Camera-type Eye Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Tissue Development Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of DNA Metabolic Process Digestive System Development Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Glomerular Capillary Formation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Retrograde Transport, Endosome To Golgi Tube Morphogenesis Endosomal Transport Metanephric Glomerulus Vasculature Development Digestive Tract Morphogenesis	Cellular Protein Localization Intracellular Protein Transport Cellular Localization Protein Folding Endocytosis Protein Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Transport Vesicle-mediated Transport Developmental Process Negative Regulation Of Hyaluronan Biosynthetic Process Heme Oxidation Anatomical Structure Development Lamellipodium Morphogenesis
Tagcloud ?		assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35	counteracted egf egfr endosomal endosomes escrt generating ilvs intraluminal laptm4b lysosomal machineries mves neutralizes oncoprotein p2 pip pipkigammai5 promoting ptdins recruiting sorting termination transform transmembrane ubiquitinated ubiquitination vesicles vesicular
Tagcloud (Difference) ?		assembles assembling autonomously cation comprises conflicting heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 subcomplexes tgn truly vps26 vps29 vps35	counteracted egf egfr escrt generating ilvs intraluminal laptm4b lysosomal machineries mves neutralizes oncoprotein p2 pip pipkigammai5 promoting ptdins recruiting termination transform transmembrane ubiquitinated ubiquitination vesicles vesicular
Tagcloud (Intersection) ?		endosomal endosomes sorting