FUBP1 and GTF2H1

Number of citations of the paper that reports this interaction (PMID 11239393)
31

Data Source:
HPRD (in vitro, in vivo)

		FUBP1	GTF2H1
Gene Name		far upstream element (FUSE) binding protein 1	general transcription factor IIH, polypeptide 1, 62kDa
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways			RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)
Protein-Protein Interactions		13 interactors: AIMP2 CCNH CELF1 CHD3 CRMP1 GTF2H1 IMMT MAPK14 MYOC PUF60 SMN1 TLE1 VIM	42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1
Entrez ID		8880	2965
HPRD ID		10349	01807
Ensembl ID		ENSG00000162613	ENSG00000110768
Uniprot IDs		B4DT31 Q96AE4	P32780
PDB IDs		1J4W 2KXH	1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Nitrogen Compound Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Regulation Of Gene Expression, Epigenetic Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Spliceosomal Complex Assembly Transcription Elongation From RNA Polymerase II Promoter ERBB2-ERBB3 Signaling Pathway P38MAPK Cascade Skeletal Muscle Hypertrophy Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic RNA Splicing Positive Regulation Of Gene Expression RNA Biosynthetic Process DNA-templated Transcription, Elongation Regulation Of Metabolic Process Nucleotide-excision Repair ERBB2 Signaling Pathway Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Apoptotic Process Regulation Of Gene Expression Anatomical Structure Development Macromolecule Biosynthetic Process Glial Cell Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Programmed Cell Death Cell Death Death Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process	Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress
Tagcloud ?		19q 1p anaplastic arms astrocytic astrocytoma atrx cdkn2a cic displays endogenously expresses gliomas histopathology hydroxyglutarate idh1 infiltrating investigating isocitrate jhh ketoglutarate lengthening oligodendrocytic r132h scarcity subgroup telomeres unfortunately vast
Tagcloud (Difference) ?		19q 1p anaplastic arms astrocytic astrocytoma atrx cdkn2a cic displays endogenously expresses gliomas histopathology hydroxyglutarate idh1 infiltrating investigating isocitrate jhh ketoglutarate lengthening oligodendrocytic r132h scarcity subgroup telomeres unfortunately vast
Tagcloud (Intersection) ?