KRTAP22-1 and CHRD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP22-1	CHRD
Description		keratin associated protein 22-1	chordin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Extracellular Region Extracellular Space
	Molecular Function		Protein Binding Cytokine Binding BMP Binding
	Biological Process		Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation Pattern Specification Process Dorsal/ventral Pattern Formation Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion System Development
Pathways		Keratinization
Drugs
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 20139978 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		14 interacting genes: ARID5A CAMK2A CHRD CREB5 FOXD2 MEIS2 MGAT5B OTX1 RNF44 SMARCC1 SNRPC VENTX ZIC1 ZNHIT2	60 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R FXR1 FXR2 GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 NUFIP2 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1
Entrez ID		337979	8646
HPRD ID		11216	04592
Ensembl ID		ENSG00000186924	ENSG00000090539
Uniprot IDs		Q3MIV0	E7ESX1 Q8N2W7 Q9H2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-threonine Autophosphorylation DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diencephalon Morphogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Inner Ear Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Forebrain Development DNA-binding Transcription Factor Activity Regulation Of Endocannabinoid Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cardiac Muscle Myoblast Proliferation Metencephalon Development	Intermediate Filament Keratin Filament Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Epidermis Development Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Positive Regulation Of Blood Coagulation Keratinization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Osteoblast Proliferation Pericardium Development Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Developmental Process Animal Organ Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesoderm Formation Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Transcription Coactivator Binding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Proliferation Branch Elongation Of An Epithelium Inner Ear Development Nuclear Glucocorticoid Receptor Binding Hair Cycle Ossification Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer MAPK Cascade Epithelium Development Regulation Of Wound Healing Negative Regulation Of Small GTPase Mediated Signal Transduction
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