CFAP298 and RFX5

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CFAP298	RFX5
Description		cilia and flagella associated protein 298	regulatory factor X5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cilium Movement Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS			Body mass index ( 26426971)
Interacting Genes		21 interacting genes: APP COPS5 ERBB2 EWSR1 FMN2 GMCL1 KPNA4 MAPK6 NCOA2 PAX6 PTGER4 RANBP9 RFX5 RPH3A SNRNP70 SPTBN4 TAF1 TRPS1 UNC13B ZNF521 ZNF624	6 interacting genes: APP CFAP298 CIITA HDAC2 RFXANK RFXAP
Entrez ID		56683	5993
HPRD ID		10756	03517
Ensembl ID		ENSG00000159079	ENSG00000143390
Uniprot IDs		C9J818 D3DSE6 P57076	P48382
PDB IDs			2KW3 3V30
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Axonogenesis Neuromuscular Junction Development Nucleoplasm Secretion By Cell Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Neuron Fate Commitment Establishment Of Organelle Localization Negative Regulation Of Eosinophil Extravasation Positive Regulation Of Androgen Receptor Signaling Pathway Transcription Regulator Inhibitor Activity Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Locomotory Behavior MRNA Transcription By RNA Polymerase II Establishment Of Localization In Cell Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process	Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Dendrite Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Nucleus Positive Regulation Of Male Mating Behavior Positive Regulation Of Interleukin-1 Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Golgi Lumen Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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