CFAP298 and TRPS1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CFAP298	TRPS1
Description		cilia and flagella associated protein 298	transcriptional repressor GATA binding 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection	Chromatin Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Cilium Movement Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Chondrocyte Differentiation Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases			Trichorhinophalangeal dysplasia
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Asthma ( 29273806) Basal cell carcinoma ( 31174203) Brain morphology (MOSTest) ( 32665545) Bronchopulmonary dysplasia ( 23897914) C-reactive protein levels ( 30388399) Cholesterol, total ( 20686565) Chronotype ( 30696823) Cognitive decline (age-related) ( 28078323) Cutaneous squamous cell carcinoma ( 27424798 32041948) Disability (impaired activities of daily living) ( 31707593) Diverticular disease ( 30177863) Eating disorders ( 22911880) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) HDL cholesterol ( 30275531 20686565 24097068) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Low tan response ( 29739929) Major depressive disorder ( 22472876) Male-pattern baldness ( 28196072) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Morning person ( 30696823) Night sleep phenotypes ( 27126917) Parkinson's disease (familial, age at onset) ( 27402877) Periodontal microbiota ( 22699663) Platelet count ( 29403010) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Severe influenza A (H1N1) infection ( 26379185) Squamous cell carcinoma ( 31174203) Total cholesterol levels ( 29403010 30275531 33339817) Triglyceride levels ( 32203549) Urate levels (BMI interaction) ( 25811787) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		21 interacting genes: APP COPS5 ERBB2 EWSR1 FMN2 GMCL1 KPNA4 MAPK6 NCOA2 PAX6 PTGER4 RANBP9 RFX5 RPH3A SNRNP70 SPTBN4 TAF1 TRPS1 UNC13B ZNF521 ZNF624	4 interacting genes: CFAP298 RNF4 SUMO1 UBE2I
Entrez ID		56683	7227
HPRD ID		10756	05091
Ensembl ID		ENSG00000159079	ENSG00000104447
Uniprot IDs		C9J818 D3DSE6 P57076	Q9UHF7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Axonogenesis Neuromuscular Junction Development Nucleoplasm Secretion By Cell Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Neuron Fate Commitment Establishment Of Organelle Localization Negative Regulation Of Eosinophil Extravasation Positive Regulation Of Androgen Receptor Signaling Pathway Transcription Regulator Inhibitor Activity Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Locomotory Behavior MRNA Transcription By RNA Polymerase II Establishment Of Localization In Cell Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process	Small Protein Activating Enzyme Binding PML Body Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol Nuclear Body Protein Sumoylation Nuclear Pore Protein Modification By Small Protein Conjugation SUMO Conjugating Enzyme Activity Post-translational Protein Modification Regulation Of Kinetochore Assembly RING-like Zinc Finger Domain Binding Protein Localization To Nuclear Pore Negative Regulation Of Protein Localization SUMO Ligase Complex HLH Domain Binding SUMO Polymer Binding Negative Regulation Of Action Potential Regulation Of Microtubule-based Process Regulation Of Centromere Complex Assembly Negative Regulation Of Protein Localization To Chromatin Microtubule End PML Body Organization Negative Regulation Of Delayed Rectifier Potassium Channel Activity Nuclear Stress Granule Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Regulation Of Protein Localization To Chromatin Regulation Of Delayed Rectifier Potassium Channel Activity Mitotic Nuclear Membrane Reassembly Transporter Activator Activity Nucleoplasm Protein Modification Process Enzyme Binding Transferase Complex Protein Localization To Nuclear Envelope Regulation Of Protein-containing Complex Assembly XY Body Protein Tag Activity Negative Regulation Of DNA Binding Nuclear Body Organization Negative Regulation Of Protein Import Into Nucleus Ubiquitin-specific Protease Binding SUMO Transferase Activity Cellular Response To Cadmium Ion Negative Regulation Of Potassium Ion Transmembrane Transport Protein K6-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Nuclear Membrane Reassembly
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