RCOR1 and SMARCE1

Number of citations of the paper that reports this interaction (PMID 12192000)
45

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RCOR1	SMARCE1
Gene Name		REST corepressor 1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex	Nuclear Chromosome Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Transcriptional Repressor Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Ligand-dependent Nuclear Receptor Binding Nucleosomal DNA Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Blood Coagulation Viral Process Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Metabolic Process ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		10 interactors: CTBP1 HDAC2 HIST3H3 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 ZMYM2	63 interactors: AMOTL2 AR ARID2 BAZ1B BRMS1 CCDC136 CCDC172 CDR2 CEP170P1 CEP63 CEP70 DISC1 EPS8 ESR1 ESR2 EXOC7 GATA1 GOLGA2 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT15 KRT31 KRT40 KRTAP10-9 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NL NR0B2 NR3C1 NUP62 PGR PRMT5 RALBP1 RARA RCOR1 RELB RINT1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TFE3 TFIP11 TNIK TRIM54 TRIP10 TXLNA USHBP1
Entrez ID		23186	6605
HPRD ID		09645	04382
Ensembl ID		ENSG00000089902	ENSG00000073584
Uniprot IDs		J3KN32 Q9UKL0	Q969G3
PDB IDs		2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Modification Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Nitrogen Compound Metabolic Process Histone H4 Deacetylation Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Organelle Organization Biosynthetic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process	Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Transcription From RNA Polymerase II Promoter Chromosome Organization RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Steroid Hormone Stimulus Hormone-mediated Signaling Pathway Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Gland Development Cellular Response To Organic Cyclic Compound Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Nucleic Acid-templated Transcription Organ Development Negative Regulation Of RNA Biosynthetic Process Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction
Tagcloud ?		appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico subpopulations trithorax
Tagcloud (Difference) ?		appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico subpopulations trithorax
Tagcloud (Intersection) ?