CPSF2 and MIRLET7F2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		CPSF2	MIRLET7F2
Description		cleavage and polyadenylation specific factor 2	microRNA let-7f-2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Postsynapse Glutamatergic Synapse	RISC Complex
	Molecular Function	RNA Binding Protein Binding
	Biological Process	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		3-month functional outcome in lacunar ischaemic stroke (modified Rankin score) ( 30796134) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) Dialysis-related mortality ( 21546767) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Monobrow ( 27182965) Myopia ( 27182965) Obesity-related traits ( 23251661) Refractive error ( 32231278)	Bipolar disorder ( 31043756)
Interacting Genes		13 interacting genes: DLGAP1-AS2 MIR19A MIR19B1 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A3 MIRLET7F2 POLR2A RNF10 SUMO2 UNKL WWOX	95 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CPSF1 CPSF2 CPSF6 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2B TRIM71 TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		53981	406889
HPRD ID		05824
Ensembl ID		ENSG00000165934	ENSG00000208012
Uniprot IDs		Q9P2I0
PDB IDs		6URG 6V4X
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Extracellular Vesicle Negative Regulation Of Extracellular Matrix Organization MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Gene Expression Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Bacterial Lipopeptide Regulation Of Macromolecule Biosynthetic Process Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Motility Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Locomotion Regulation Of Extracellular Matrix Assembly Regulation Of Macromolecule Metabolic Process Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Interleukin-6 Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Translation Negative Regulation Of Striated Muscle Cell Apoptotic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Binding Nucleus Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Translation Cytoplasmic Stress Granule MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Stability MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Spliceosomal Complex MiRNA Processing Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Processing RNA 3'-end Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process RNA Stabilization Negative Regulation Of Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process Paraspeckles Nucleolus
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