CPSF2 and MIR19A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		CPSF2	MIR19A
Description		cleavage and polyadenylation specific factor 2	microRNA 19a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Postsynapse Glutamatergic Synapse	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Fibroblast Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization B Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Bacterial Lipopeptide Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Cardiac Conduction Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		3-month functional outcome in lacunar ischaemic stroke (modified Rankin score) ( 30796134) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) Dialysis-related mortality ( 21546767) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Monobrow ( 27182965) Myopia ( 27182965) Obesity-related traits ( 23251661) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: DLGAP1-AS2 MIR19A MIR19B1 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A3 MIRLET7F2 POLR2A RNF10 SUMO2 UNKL WWOX	99 interacting genes: AGO2 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CRTAP CSTF2 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 P3H1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBBP6 RBFOX2 RBM12B RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 WDR33 WWP1 WWP2 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		53981	406979
HPRD ID		05824
Ensembl ID		ENSG00000165934	ENSG00000284204
Uniprot IDs		Q9P2I0
PDB IDs		6URG 6V4X
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Extracellular Vesicle Negative Regulation Of Extracellular Matrix Organization MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Gene Expression Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Bacterial Lipopeptide Regulation Of Macromolecule Biosynthetic Process Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Motility Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Locomotion Regulation Of Extracellular Matrix Assembly Regulation Of Macromolecule Metabolic Process Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Interleukin-6 Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Translation Negative Regulation Of Striated Muscle Cell Apoptotic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Nucleus Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA Cleavage And Polyadenylation Specificity Factor Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Translation RNA Splicing, Via Transesterification Reactions MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Spliceosomal Complex MiRNA Binding Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization RNA 3'-end Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability MRNA Stabilization Regulation Of RNA Stability Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Metabolic Process Regulation Of Cytoplasmic Translation
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