CHAF1A and DBF4

Number of citations of the paper that reports this interaction (PMID 16826239)
11

Data Source:
HPRD (in vivo, two hybrid)

		CHAF1A	DBF4
Gene Name		chromatin assembly factor 1, subunit A (p150)	DBF4 zinc finger
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin CAF-1 Complex Protein Complex	Nucleoplasm
	Molecular Function	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding	Nucleic Acid Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	DNA Replication DNA Repair DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Cycle Chromatin Assembly	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Positive Regulation Of Catalytic Activity
Pathways			G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B DBF4 DDX41 HIST1H3E HIST3H3 HMGB2 LZTR1 MBD1 MSH6 PABPC1 PCBD2 PCNA RBFOX2 REL SET SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408	17 interactors: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		10036	10926
HPRD ID		03148	10371
Ensembl ID		ENSG00000167670	ENSG00000006634
Uniprot IDs		Q13111	B7Z8C6 Q9UBU7
PDB IDs			4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Protein-DNA Complex Assembly Chromosome Organization Nitrogen Compound Metabolic Process Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Chromatin Assembly Nucleosome Organization Cellular Response To DNA Damage Stimulus Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process DNA Packaging Positive Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Sumoylation DNA Recombination Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Telomere Maintenance Organelle Organization DNA Replication Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Protein Complex Assembly Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process	DNA Replication DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change DNA Conformation Change Cellular Response To DNA Damage Stimulus Chromosome Organization Cellular Metabolic Process Regulation Of DNA Replication DNA Repair Cellular Response To Stress Organelle Organization Regulation Of Nuclear Cell Cycle DNA Replication Signal Transduction In Response To DNA Damage Positive Regulation Of DNA-dependent DNA Replication Metabolic Process Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To Epidermal Growth Factor Stimulus DNA Damage Checkpoint Response To Epidermal Growth Factor Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of DNA Replication Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition
Tagcloud ?		3a aggressive cohorts concept driven gsea intact malignancies malignancy mcm3 mcm6 mdm2 multifactorial networks neuroblastoma nutlin oncogene opposing overcome p53 potently reciprocally repressed repression rrm2 signature signatures subset worst	bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished
Tagcloud (Difference) ?		3a aggressive cohorts concept driven gsea intact malignancies malignancy mcm3 mcm6 mdm2 multifactorial networks neuroblastoma nutlin oncogene opposing overcome p53 potently reciprocally repressed repression rrm2 signature signatures subset worst	bud cdc28 cdc4 cdc7 cln1 cln2 cln3 commited conceivable cyclins dsc1 duplication else firstly hartley hfs1 jackson mcb p34cdc28 pole principally redundancy rosamond sbf scb scm4 smith swi6 unpublished
Tagcloud (Intersection) ?