SMPD2 and STAR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMPD2	STAR
Description		sphingomyelin phosphodiesterase 2	steroidogenic acute regulatory protein
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Caveola Membrane Cell Periphery	Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	Catalytic Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process	Lipid Metabolic Process Steroid Biosynthetic Process Lipid Transport Cholesterol Metabolic Process Glucocorticoid Metabolic Process Intracellular Cholesterol Transport Regulation Of Steroid Biosynthetic Process Positive Regulation Of Bile Acid Biosynthetic Process
Pathways		Ceramide signalling TNFR1-mediated ceramide production Glycosphingolipid catabolism	Pregnenolone biosynthesis Mitochondrial protein degradation
Drugs
Diseases			Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Height ( 18391951)	Menopause (age at onset) ( 26414677) Orthostatic hypotension ( 24124408) Schizophrenia ( 29483656)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	12 interacting genes: AGTRAP CCHCR1 CMTM4 DGAT2L6 FEZ1 LIPE MAGEA11 MAPK3 NUCB2 RABEP1 SMPD2 STX8
Entrez ID		6610	6770
HPRD ID		04608	02794
Ensembl ID		ENSG00000135587	ENSG00000147465
Uniprot IDs		O60906	P49675 Q6IBK0
PDB IDs		8J2F	3P0L 5OMA 6T5F 6T5H
Enriched GO Terms of Interacting Partners?			Caveola
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