STAR and DGAT2L6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STAR	DGAT2L6
Description		steroidogenic acute regulatory protein	diacylglycerol O-acyltransferase 2 like 6
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity	Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Lipid Transport Cholesterol Metabolic Process Glucocorticoid Metabolic Process Intracellular Cholesterol Transport Regulation Of Steroid Biosynthetic Process Positive Regulation Of Bile Acid Biosynthetic Process	Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Acylglycerol Acyl-chain Remodeling
Pathways		Pregnenolone biosynthesis Mitochondrial protein degradation	Acyl chain remodeling of DAG and TAG
Drugs
Diseases		Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Menopause (age at onset) ( 26414677) Orthostatic hypotension ( 24124408) Schizophrenia ( 29483656)
Interacting Genes		12 interacting genes: AGTRAP CCHCR1 CMTM4 DGAT2L6 FEZ1 LIPE MAGEA11 MAPK3 NUCB2 RABEP1 SMPD2 STX8	45 interacting genes: ABHD4 ABHD5 ACSF2 AQP6 ARFIP2 BNIP2 CIAO2A DIABLO ECPAS FARS2 FBXL19 FCER1G GAD2 GPR152 HSD17B11 MCEMP1 MPP1 MTERF4 MYG1 NAPB NDRG4 PBX3 PGRMC2 PITPNC1 REEP4 RNF144A RNF5 RUSF1 SCAND1 SCN3B SLC10A1 SLC10A6 SMG9 SNX4 STAR THAP4 TMED8 TMEM143 TMEM14B TMEM255B TMEM31 TMX2 TTPA TUFM WIPI2
Entrez ID		6770	347516
HPRD ID		02794	13141
Ensembl ID		ENSG00000147465	ENSG00000184210
Uniprot IDs		P49675 Q6IBK0	Q6ZPD8
PDB IDs		3P0L 5OMA 6T5F 6T5H
Enriched GO Terms of Interacting Partners?		Caveola
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