SMPD2

Gene Name		sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Metal Ion Binding
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Metabolic Process Glycosphingolipid Metabolic Process Response To Mechanical Stimulus Intracellular Signal Transduction Small Molecule Metabolic Process Ceramide Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways		Signalling by NGF Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Ceramide signalling p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-protein Interactions		1 interactors: PIK3CG
Entrez ID		6610
HPRD ID		04608
Ensembl ID		ENSG00000135587
Uniprot IDs		O60906
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Respiratory Burst Involved In Defense Response Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Striated Muscle Contraction Secretory Granule Localization T Cell Chemotaxis Negative Regulation Of Fibroblast Apoptotic Process Respiratory Burst Dendritic Cell Chemotaxis Lymphocyte Chemotaxis T Cell Migration Hepatocyte Apoptotic Process Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Muscle Contraction Phosphatidylinositol-3-phosphate Biosynthetic Process Negative Regulation Of Heart Contraction Negative Regulation Of Lipid Catabolic Process Phosphatidylinositol 3-kinase Signaling Dendritic Cell Migration Mast Cell Degranulation Positive Regulation Of Acute Inflammatory Response Cellular Extravasation Lymphocyte Migration Mast Cell Mediated Immunity Regulation Of Triglyceride Metabolic Process Lysosome Localization Mast Cell Activation Platelet Aggregation Regulation Of Cell Adhesion Mediated By Integrin Leukocyte Degranulation Neutrophil Chemotaxis Neutrophil Migration Regulated Secretory Pathway Regulation Of Lipid Catabolic Process Granulocyte Chemotaxis T Cell Proliferation Regulation Of Acute Inflammatory Response Regulation Of Cardiac Muscle Contraction Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Kinase B Signaling Phosphatidylinositol Phosphorylation Regulation Of Striated Muscle Contraction Lipid Phosphorylation Positive Regulation Of Inflammatory Response Leukocyte Chemotaxis Lymphocyte Proliferation Mononuclear Cell Proliferation Phosphatidylinositol Biosynthetic Process
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