CDX2 and ACAT2

Number of citations of the paper that reports this interaction (PubMedID 12518221)
0

Data Source:
HPRD (in vivo)

		CDX2	ACAT2
Description		caudal type homeobox 2	acetyl-CoA acetyltransferase 2
Image
GO Annotations	Cellular Component	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcription Repressor Complex Protein-containing Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Acetyl-CoA C-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Blastocyst Development Trophectodermal Cell Differentiation Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Positive Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development	Lipid Metabolic Process Fatty Acid Metabolic Process
Pathways		Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Cholesterol biosynthesis
Drugs			S-Hydroxycysteine Coenzyme A
Diseases
GWAS		Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)	Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 30108283)
Interacting Genes		18 interacting genes: ACAT2 ATM CDK2 CFAP206 CREBBP DNMT3L EP300 GSK3B HNF1A KRTAP4-12 MAPK1 MAPK14 MRE11 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB	7 interacting genes: AKT1 CDX2 CSNK2A1 LNX1 TERF1 WWOX ZNF76
Entrez ID		1045	39
HPRD ID		02622	00006
Ensembl ID		ENSG00000165556	ENSG00000120437
Uniprot IDs		Q99626	Q9BWD1
PDB IDs		5LTY 6ES2 6ES3 7Q4N	1WL4 1WL5
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Heat Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair P53 Binding Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Myoblast Differentiation Regulation Of Cell Cycle Phase Transition Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression, Epigenetic NpBAF Complex Regulation Of Mitotic Cell Cycle RSC-type Complex NBAF Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Meiosis I Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Organelle Organization Histone H3K27 Acetyltransferase Activity Regulation Of Myoblast Differentiation Nucleosome Disassembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Glucose Mediated Signaling Pathway	Identical Protein Binding Execution Phase Of Apoptosis Negative Regulation Of Translational Initiation Spindle Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of TRNA Methylation Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Differentiation Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Nervous System Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Proteolysis TRNA (guanine-N7)-methylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Regulation Of Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of DNA Metabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Rapamycin Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric-oxide Synthase Regulator Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation
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