BAZ1B

Name	bromodomain adjacent to zinc finger domain 1B
Structure
Interactors	16 interactors: CDT1 H2AX KANSL1 KAT8 MAILR MTNR1A MYO1C NR4A2 PCNA RNF10 SIRT1 SMARCA1 SMARCA5 SMARCC2 SMARCE1 SUMO2
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Nuclear Replication Fork WICH Complex B-WICH Complex
	Molecular Function	Nucleotide Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone Binding Metal Ion Binding Histone H2AXY142 Kinase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Mitotic Chromosome Condensation
Pathways	B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
GWAS	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Hip index ( 34021172 ) Hypertriglyceridemia ( 23505323 ) Hyperuricemia ( 29124443 ) Lamb consumption ( 32066663 ) Lipoprotein (a) levels ( 33730874 ) Malaria ( 31844061 ) Meat-related diet ( 32066663 ) Metabolic syndrome ( 31589552 ) Migraine ( 27182965 ) Non-oily fish consumption ( 32066663 ) Platelet count ( 32888494 ) Protein C levels ( 20802025 ) Pursuit maintenance gain ( 29064472 ) Serum alkaline phosphatase levels ( 33339817 ) Serum uric acid levels ( 30993211 ) Triglyceride levels ( 32203549 ) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818 ) Triglycerides ( 20864672 ) Urate levels ( 31985003 23263486 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )
Entrez ID	9031
HPRD ID	10416
Ensembl ID	ENSG00000009954
Uniprot IDs	Q9UIG0
PDB IDs	1F62 5NNF
GO Terms Enriched among Interactors ?	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Heterochromatin Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Kinetochore Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Double-strand Break Repair Chromatin Regulation Of DNA Repair Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression CERF Complex Nucleosome Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleosome Array Spacer Activity Regulation Of Double-strand Break Repair Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Histone Binding NURF Complex RDNA Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromosome B-WICH Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process BBAF Complex Regulation Of Mitochondrial Transcription Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex