TACC2 and AURKC

Number of citations of the paper that reports this interaction (PMID 14602875)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TACC2	AURKC
Gene Name		transforming, acidic coiled-coil containing protein 2	aurora kinase C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Microtubule Cytoskeleton	Condensed Nuclear Chromosome, Centromeric Region Condensed Chromosome Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone
	Molecular Function	Protein Domain Specific Binding Nuclear Hormone Receptor Binding	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Histone Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Astral Microtubule Organization Regulation Of Microtubule-based Process	Cytokinesis Protein Phosphorylation Attachment Of Spindle Microtubules To Kinetochore Regulation Of Signal Transduction Histone Modification Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Mitotic Spindle Midzone Assembly Meiotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: AURKC CREBBP EP300 HMG20B KAT2A KAT2B PPP1CC RXRB SMARCB1 UBC YEATS4	10 interactors: BIRC5 BRCA1 CENPA HIST1H3A INCENP LNX1 NEDD4 NEDD4L SRPK1 TACC2
Entrez ID		10579	6795
HPRD ID		05600	04605
Ensembl ID		ENSG00000138162	ENSG00000105146
Uniprot IDs		D6RAA5 E7EMZ9 E9PBC6 O95359 Q4VXL8	Q5Y191 Q9UQB9
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Modification N-terminal Peptidyl-lysine Acetylation Chromatin Organization Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Chromosome Organization Protein Acetylation Histone Modification Positive Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Cell Cycle Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Peptidyl-lysine Modification Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Notch Signaling Pathway Mitotic Cell Cycle RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Gene Expression Regulation Of Gene Expression Peptidyl-amino Acid Modification Histone H4 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription In Response To Stress Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Process Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Protein Modification By Small Protein Conjugation Negative Regulation Of Sodium Ion Transport Microtubule Cytoskeleton Organization Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process DNA Packaging Regulation Of Potassium Ion Transmembrane Transporter Activity Organelle Organization Negative Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Biosynthetic Process Cell Cycle Protein Monoubiquitination DNA Conformation Change Microtubule-based Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Histone H4-K16 Acetylation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Complex Assembly Organelle Localization Negative Regulation Of Ion Transport Cellular Protein Modification Process Cytoskeleton Organization Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Type B Pancreatic Cell Proliferation Cytokinesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleosome Assembly Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Spindle Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process
Tagcloud ?		abundantly affymetrix annotated ccnd1 crmp1 curing cycles ddc endpoint gabrb3 hurdle hydroxylase immunotherapy isl1 kif1a marrows mrd neuroblastoma phox2b prioritize profiling ranking sampled serves stringent surrogate top u95 uncover	alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation
Tagcloud (Difference) ?		abundantly affymetrix annotated ccnd1 crmp1 curing cycles ddc endpoint gabrb3 hurdle hydroxylase immunotherapy isl1 kif1a marrows mrd neuroblastoma phox2b prioritize profiling ranking sampled serves stringent surrogate top u95 uncover	alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation
Tagcloud (Intersection) ?