ETV5 and DHRS7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ETV5	DHRS7
Description		ETS variant transcription factor 5	dehydrogenase/reductase 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuromuscular Synaptic Transmission Locomotory Behavior Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Regulation Of Synapse Organization Positive Regulation Of Glial Cell Proliferation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering	Retinol Metabolic Process
Pathways
Drugs
Diseases		Prostate cancer
GWAS		Adult body size ( 32376654) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 19079260 20935630 29381148 23563607 28892062 25673413 28552196 26961502 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31451708 31152163 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) Hip circumference ( 25673412) Hyperuricemia ( 29124443) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 27182965 21102462) Obesity ( 23563607) Platelet distribution width ( 32888494) Serum uric acid levels ( 29124443) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference ( 25673412) Weight ( 19079260)	Allergic rhinitis ( 22036096) Optic disc size ( 31809533)
Interacting Genes		14 interacting genes: AMH APP AR BRCA1 CCR5 CHD3 CISH CYP3A5 DHRS7 GRAP2 HOXD9 MFHAS1 SEZ6L2 SLC22A2	4 interacting genes: ETV5 GLP1R HRH1 SACM1L
Entrez ID		2119	51635
HPRD ID		09035	16802
Ensembl ID		ENSG00000244405	ENSG00000100612
Uniprot IDs		P41161	Q9Y394
PDB IDs		4UNO 5ILV
Enriched GO Terms of Interacting Partners?		Leydig Cell Differentiation Adult Locomotory Behavior Cell-cell Signaling Cell Communication Sex Determination Signaling Low-density Lipoprotein Particle Receptor Binding Adult Behavior Positive Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Locomotory Behavior Prostate Induction Regulation Of Intracellular Estrogen Receptor Signaling Pathway Male Somatic Sex Determination Centrosome Cycle Retinol Metabolic Process Developmental Growth Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Ovarian Follicle Development Mullerian Duct Regression Development Of Primary Male Sexual Characteristics Preantral Ovarian Follicle Growth Regulation Of Ovarian Follicle Development Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Axon Midline Choice Point Recognition Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium	Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Male Germ-line Stem Cell Asymmetric Division Chemical Synaptic Transmission Response To Psychosocial Stress Regulation Of Blood Circulation Learning Or Memory Post-translational Protein Targeting To Membrane, Translocation Cognition Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Cellular Response To Histamine Phospholipase C-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Endoplasmic Reticulum-plasma Membrane Contact Site Trans-synaptic Signaling Synaptic Signaling Cellular Response To Glucagon Stimulus Response To Histamine G Protein-coupled Receptor Activity Asymmetric Cell Division Secretion By Cell Activation Of Adenylate Cyclase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Response To Glucagon G Protein-coupled Serotonin Receptor Signaling Pathway Secretion Positive Regulation Of Cyclase Activity Stem Cell Division Positive Regulation Of Glial Cell Proliferation Phosphatidylinositol Dephosphorylation Regulation Of System Process Positive Regulation Of Vasoconstriction AMPA Glutamate Receptor Complex Cell-cell Signaling Intracellular Protein Transmembrane Transport Positive Regulation Of Blood Pressure Neuromuscular Synaptic Transmission Signaling Cell Communication Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Phospholipid Dephosphorylation Regulation Of Glial Cell Proliferation
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