ETV5 and CYP3A5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ETV5	CYP3A5
Gene Name		ets variant 5	cytochrome P450, family 3, subfamily A, polypeptide 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Neuromuscular Synaptic Transmission Locomotory Behavior Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Male Germ-line Stem Cell Asymmetric Division Regulation Of Synapse Organization Positive Regulation Of Glial Cell Proliferation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering	Xenobiotic Metabolic Process Steroid Metabolic Process Alkaloid Catabolic Process Drug Catabolic Process Small Molecule Metabolic Process Oxidative Demethylation
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations Defective ACY1 causes encephalopathy
Drugs			Paliperidone
Diseases
GWAS		Body mass index ( 23563607 19079260 20935630) Menarche (age at onset) ( 21102462) Obesity ( 23563607) Weight ( 19079260)
Protein-Protein Interactions		11 interactors: AMH APP AR BRCA1 CCR5 CISH CYP3A5 DHRS7 HOXD9 SEZ6L2 SLC22A2	3 interactors: ATOH8 ETV5 RDH13
Entrez ID		2119	1577
HPRD ID		09035	05617
Ensembl ID		ENSG00000244405	ENSG00000106258
Uniprot IDs		P41161	P20815 Q7Z3N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase III Promoter Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Intracellular Steroid Hormone Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation Preantral Ovarian Follicle Growth Adult Locomotory Behavior Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Histone H4 Acetylation Alkaloid Catabolic Process Negative Regulation Of Histone H3-K4 Methylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Reproductive Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Cytokine Stimulus Regulation Of Integrin Biosynthetic Process Cell Growth Cellular Response To Indole-3-methanol Collateral Sprouting Axon Midline Choice Point Recognition Response To Organic Substance Adult Behavior Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Response To Cytokine Cell Communication Dosage Compensation By Inactivation Of X Chromosome Axon Choice Point Recognition Oogenesis Stage Positive Regulation Of Cellular Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Protein K6-linked Ubiquitination Gonadal Mesoderm Development Mullerian Duct Regression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H3-K9 Methylation	Response To High Light Intensity Male Germ-line Stem Cell Asymmetric Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Nervous System Development Response To Light Intensity Positive Regulation Of Glial Cell Proliferation Neuromuscular Synaptic Transmission Cell Differentiation Retina Layer Formation Postsynaptic Membrane Organization Eye Photoreceptor Cell Development Stem Cell Division System Development Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation Receptor Clustering Neuromuscular Junction Development Neural Retina Development Positive Regulation Of Gliogenesis Retina Morphogenesis In Camera-type Eye Regulation Of Morphogenesis Of A Branching Structure Multicellular Organismal Development Anatomical Structure Development
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated exhibits fbln1 filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	antifungal concomitant contributed cyp2c19 delivered explained genotype hsct imply institute interindividual intravenous lansoprazole magnitude march mie odds polymorphism possession ratio recipient recipients tac tacrolimus triazole variability voriconazole vrcz
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated exhibits fbln1 filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	antifungal concomitant contributed cyp2c19 delivered explained genotype hsct imply institute interindividual intravenous lansoprazole magnitude march mie odds polymorphism possession ratio recipient recipients tac tacrolimus triazole variability voriconazole vrcz
Tagcloud (Intersection) ?