ETV5 and CISH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ETV5	CISH
Description		ETS variant transcription factor 5	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane Synapse	Cytosol Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Cytokine Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuromuscular Synaptic Transmission Locomotory Behavior Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Regulation Of Synapse Organization Positive Regulation Of Glial Cell Proliferation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering	Regulation Of Cell Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways			Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs
Diseases		Prostate cancer
GWAS		Adult body size ( 32376654) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 19079260 20935630 29381148 23563607 28892062 25673413 28552196 26961502 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31451708 31152163 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) Hip circumference ( 25673412) Hyperuricemia ( 29124443) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 27182965 21102462) Obesity ( 23563607) Platelet distribution width ( 32888494) Serum uric acid levels ( 29124443) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference ( 25673412) Weight ( 19079260)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: AMH APP AR BRCA1 CCR5 CHD3 CISH CYP3A5 DHRS7 GRAP2 HOXD9 MFHAS1 SEZ6L2 SLC22A2	20 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA JAK1 JAK2 JAK3 KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		2119	1154
HPRD ID		09035	03897
Ensembl ID		ENSG00000244405	ENSG00000114737
Uniprot IDs		P41161	Q9NSE2
PDB IDs		4UNO 5ILV
Enriched GO Terms of Interacting Partners?		Leydig Cell Differentiation Adult Locomotory Behavior Cell-cell Signaling Cell Communication Sex Determination Signaling Low-density Lipoprotein Particle Receptor Binding Adult Behavior Positive Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Locomotory Behavior Prostate Induction Regulation Of Intracellular Estrogen Receptor Signaling Pathway Male Somatic Sex Determination Centrosome Cycle Retinol Metabolic Process Developmental Growth Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Ovarian Follicle Development Mullerian Duct Regression Development Of Primary Male Sexual Characteristics Preantral Ovarian Follicle Growth Regulation Of Ovarian Follicle Development Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Axon Midline Choice Point Recognition Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium	Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytokine Binding Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT External Side Of Plasma Membrane Protein Phosphorylation Regulation Of Cell Population Proliferation Response To Cytokine Response To Peptide Signal Transduction Phosphorylation Growth Hormone Receptor Signaling Pathway Plasma Membrane Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Protein Kinase Activity Erythropoietin-mediated Signaling Pathway Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Kinase Activity Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Diacylglycerol-dependent Serine/threonine Kinase Activity Adaptive Immune Response Interleukin-3 Receptor Activity Histone H3T6 Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Intracellular Signal Transduction Leukocyte Activation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-17 Production Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Platelet Aggregation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
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