SLC22A1 and TMEM147

Number of citations of the paper that reports this interaction (PubMedID 31318583)
0

Data Source:
BioGRID (protein complementation assay)

		SLC22A1	TMEM147
Description		solute carrier family 22 member 1	transmembrane protein 147
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GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Presynapse	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane Protein-containing Complex Multi-pass Translocon Complex
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity	Protein Binding Ribosome Binding
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Monoamine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Dopamine Transport Norepinephrine Transport Thiamine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Metanephric Proximal Tubule Development Purine-containing Compound Transmembrane Transport Dopamine Uptake Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier (R)-carnitine Transmembrane Transport O-acyl-L-carnitine Transmembrane Transport Spermidine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier	Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations Ciprofloxacin ADME
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 21743057 26034056) Serum metabolite levels ( 33031748 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995 29545352)	Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		27 interacting genes: ALDOA CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM KRTCAP2 LAPTM4A LAPTM4B MUC1 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB	61 interacting genes: ABHD16A ABI3 BIK CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 CYB5R3 DPM3 EBP EFNA4 ENPP4 ERGIC3 F11R FAM209A FFAR2 FKBP7 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SAR1A SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12
Entrez ID		6580	10430
HPRD ID		04007	17633
Ensembl ID		ENSG00000175003	ENSG00000105677
Uniprot IDs		O15245	Q9BVK8
PDB IDs		8ET6 8ET7 8ET8 8JTS 8JTT 8JTV 8JTW 8JTX 8JTY 8JTZ 8JU0 8SC1 8SC2 8SC3 8SC4 8SC6	6W6L 9C7U 9C7V
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Unfolded Protein Response Multivesicular Body, Internal Vesicle Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration	Membrane Neurotransmitter Reuptake Norepinephrine Uptake Serotonin Uptake Norepinephrine Transport Neurotransmitter Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane G Protein-coupled Receptor Activity Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Dopamine Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Actin-based Cell Projection Neurotransmitter Transport Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Transmembrane Transport Amine Transport Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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