TMEM147 and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		TMEM147	CYB5R3
Description		transmembrane protein 147	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane Protein-containing Complex Multi-pass Translocon Complex	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Ribosome Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding
	Biological Process	Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways			Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)	Initial pursuit acceleration ( 29064472)
Interacting Genes		61 interacting genes: ABHD16A ABI3 BIK CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 CYB5R3 DPM3 EBP EFNA4 ENPP4 ERGIC3 F11R FAM209A FFAR2 FKBP7 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SAR1A SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12	78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15
Entrez ID		10430	1727
HPRD ID		17633	08942
Ensembl ID		ENSG00000105677	ENSG00000100243
Uniprot IDs		Q9BVK8	P00387
PDB IDs		6W6L 9C7U 9C7V	1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Neurotransmitter Reuptake Norepinephrine Uptake Serotonin Uptake Norepinephrine Transport Neurotransmitter Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane G Protein-coupled Receptor Activity Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Dopamine Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Actin-based Cell Projection Neurotransmitter Transport Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Transmembrane Transport Amine Transport Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport
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