SLC22A1 and CERS2

Number of citations of the paper that reports this interaction (PMID 11543633)
7

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SLC22A1	CERS2
Gene Name		solute carrier family 22 (organic cation transporter), member 1	ceramide synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Dopamine Transmembrane Transporter Activity Norepinephrine Transmembrane Transporter Activity Protein Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Protein Homodimerization Activity	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Dopamine Transport Norepinephrine Transport Small Molecule Metabolic Process Epinephrine Transport Protein Homooligomerization Transmembrane Transport Ammonium Transmembrane Transport Acetate Ester Transport	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways		Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Neurotransmitter Clearance In The Synaptic Cleft Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism Transmission across Chemical Synapses	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Metabolic traits ( 21886157) Prostate cancer ( 21743057)	Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		2 interactors: CERS2 POU2AF1	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		6580	29956
HPRD ID		04007	06080
Ensembl ID		ENSG00000175003	ENSG00000143418
Uniprot IDs		O15245	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?			Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		adopted agonists cation cml endocrine hence hoct1 imatinib improve killing leukaemia myeloid organic orphan peroxisome potentially ppar predictor pregnane proliferator pxr rank rar retinoid rxr transporter upregulated uptake wilcoxon	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?		adopted agonists cation cml endocrine hence hoct1 imatinib improve killing leukaemia myeloid organic orphan peroxisome potentially ppar predictor pregnane proliferator pxr rank rar retinoid rxr transporter upregulated uptake wilcoxon	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?