SLC22A1 and SMIM24

Number of citations of the paper that reports this interaction (PubMedID 31318583)
0

Data Source:
BioGRID (protein complementation assay)

		SLC22A1	SMIM24
Description		solute carrier family 22 member 1	small integral membrane protein 24
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Presynapse	Membrane
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity	Molecular_function
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Monoamine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Dopamine Transport Norepinephrine Transport Thiamine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Metanephric Proximal Tubule Development Purine-containing Compound Transmembrane Transport Dopamine Uptake Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier (R)-carnitine Transmembrane Transport O-acyl-L-carnitine Transmembrane Transport Spermidine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier	Biological_process
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations Ciprofloxacin ADME
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 21743057 26034056) Serum metabolite levels ( 33031748 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995 29545352)
Interacting Genes		27 interacting genes: ALDOA CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM KRTCAP2 LAPTM4A LAPTM4B MUC1 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB	1 interacting genes: SLC22A1
Entrez ID		6580	284422
HPRD ID		04007	19537
Ensembl ID		ENSG00000175003	ENSG00000095932
Uniprot IDs		O15245	O75264
PDB IDs		8ET6 8ET7 8ET8 8JTS 8JTT 8JTV 8JTW 8JTX 8JTY 8JTZ 8JU0 8SC1 8SC2 8SC3 8SC4 8SC6
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Unfolded Protein Response Multivesicular Body, Internal Vesicle Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration	(R)-carnitine Transmembrane Transport Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity Spermidine Transport Metanephric Proximal Tubule Development Epinephrine Transport Norepinephrine:sodium Symporter Activity (R)-carnitine Transport Spermidine Transmembrane Transport Putrescine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity O-acyl-L-carnitine Transmembrane Transport Thiamine Transmembrane Transport Acetylcholine Transmembrane Transporter Activity Carnitine Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Proximal Tubule Development Carnitine Transmembrane Transport Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Amino-acid Betaine Transport Quaternary Ammonium Group Transport Catecholamine Uptake Dopamine Uptake Prostaglandin Transport Serotonin Transport Metanephric Nephron Tubule Development Pyrimidine-containing Compound Transmembrane Transport Metanephric Tubule Development Metanephric Epithelium Development Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Dopamine Transport Neurotransmitter Reuptake Nephron Tubule Development
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