TMEM147 and ENPP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM147	ENPP4
Description		transmembrane protein 147	ectonucleotide pyrophosphatase/phosphodiesterase 4
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane Protein-containing Complex Multi-pass Translocon Complex	Plasma Membrane Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Ribosome Binding	Protein Binding Hydrolase Activity Metal Ion Binding Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane	Blood Coagulation Hemostasis Positive Regulation Of Blood Coagulation Purine Ribonucleoside Catabolic Process
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma trimethylamine N-oxide levels ( 28439531) Platelet distribution width ( 32888494)
Interacting Genes		61 interacting genes: ABHD16A ABI3 BIK CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 CYB5R3 DPM3 EBP EFNA4 ENPP4 ERGIC3 F11R FAM209A FFAR2 FKBP7 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SAR1A SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12	2 interacting genes: TMBIM6 TMEM147
Entrez ID		10430	22875
HPRD ID		17633	16862
Ensembl ID		ENSG00000105677	ENSG00000001561
Uniprot IDs		Q9BVK8	Q9Y6X5
PDB IDs		6W6L 9C7U 9C7V	4LQY 4LR2
Enriched GO Terms of Interacting Partners?		Membrane Neurotransmitter Reuptake Norepinephrine Uptake Serotonin Uptake Norepinephrine Transport Neurotransmitter Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane G Protein-coupled Receptor Activity Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Dopamine Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Actin-based Cell Projection Neurotransmitter Transport Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Transmembrane Transport Amine Transport Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Negative Regulation Of Calcium Ion Transport Into Cytosol Endoribonuclease Inhibitor Activity IRE1-mediated Unfolded Protein Response Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Negative Regulation Of Cellular Response To Hypoxia Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Immunoglobulin Production Protein Localization To Nuclear Envelope Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing Protein Insertion Into ER Membrane Endoplasmic Reticulum Membrane Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Protein Insertion Into Membrane Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Ribosome Binding Regulation Of Immunoglobulin Production Response To Unfolded Protein Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Monoatomic Ion Transport
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