TMEM147 and LHFPL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM147	LHFPL2
Description		transmembrane protein 147	LHFPL tetraspan subfamily member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane Protein-containing Complex Multi-pass Translocon Complex	Plasma Membrane Membrane Platelet Alpha Granule Membrane
	Molecular Function	Protein Binding Ribosome Binding	Protein Binding
	Biological Process	Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane	Single Fertilization Development Of Primary Female Sexual Characteristics Development Of Primary Male Sexual Characteristics Positive Regulation Of Fertilization
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)	Birth weight ( 31043758) Blood and toenail selenium levels ( 25343990) Hippocampal atrophy ( 19668339) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 30578418 27841878)
Interacting Genes		61 interacting genes: ABHD16A ABI3 BIK CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 CYB5R3 DPM3 EBP EFNA4 ENPP4 ERGIC3 F11R FAM209A FFAR2 FKBP7 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SAR1A SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12	10 interacting genes: FXYD6 GAST GJA5 GJB1 GPR152 OLFM4 SCARF1 SNORC TMEM128 TMEM147
Entrez ID		10430	10184
HPRD ID		17633	17272
Ensembl ID		ENSG00000105677	ENSG00000145685
Uniprot IDs		Q9BVK8	Q6ZUX7
PDB IDs		6W6L 9C7U 9C7V
Enriched GO Terms of Interacting Partners?		Membrane Neurotransmitter Reuptake Norepinephrine Uptake Serotonin Uptake Norepinephrine Transport Neurotransmitter Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane G Protein-coupled Receptor Activity Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Dopamine Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Actin-based Cell Projection Neurotransmitter Transport Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Transmembrane Transport Amine Transport Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Gap Junction Assembly Gap Junction Channel Activity Connexin Complex Gap Junction Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Renin Secretion Into Blood Stream Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of AV Node Cell Action Potential Protein Localization To Nuclear Inner Membrane Regulation Of Atrial Cardiac Muscle Cell Action Potential Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Negative Regulation Of Glomerular Filtration AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell-cell Junction Assembly Gap Junction Hemi-channel Activity Connexin Binding Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Atrioventricular Valve Development AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Membrane Depolarization During Action Potential Post-chaperonin Tubulin Folding Pathway Ion Channel Regulator Activity Cell-cell Junction Organization Atrial Septum Development Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Cholesterol Catabolic Process Positive Regulation Of Axon Regeneration
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