BMP8B and SLC2A1

Data Source: HiPPIP (Novel)

		BMP8B	SLC2A1
Name		bone morphogenetic protein 8b	solute carrier family 2 member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Membrane Female Germ Cell Nucleus Photoreceptor Inner Segment Female Pronucleus Cytoplasm Cytosol Plasma Membrane Caveola Cell-cell Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Vesicle Sarcolemma Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Presynapse Glucose Transporter Complex
	Molecular Function	Cytokine Activity Growth Factor Activity	Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding Fucose Transmembrane Transporter Activity Kinase Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Skeletal System Development Ossification Cell Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Cell Differentiation Cartilage Development	Response To Hypoxia Central Nervous System Development Female Pregnancy Fucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance D-glucose Import Transmembrane Transport Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine D-glucose Transmembrane Transport
Pathways		None	Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis
Drugs		None	Resveratrol Carboxymethylcellulose
Diseases		None	GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)
GWAS		Haemorrhoidal disease ( 33888516 )	Birth weight ( 31043758 ) Cardiac hypertrophy ( 21348951 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		1 interacting genes: BMP4	18 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 TXNIP UBE2I USP2 VHL WWP1
Entrez ID		656	6513
HPRD ID		03792	00683
Ensembl ID		ENSG00000116985	ENSG00000117394
Uniprot IDs		P34820	P11166 Q59GX2
PDB IDs		Not available	4PYP 5EQG 5EQH 5EQI 6THA
GO Terms Enriched among Interactors		Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Bud Dilation Involved In Lung Branching Apoptotic Process Involved In Endocardial Cushion Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Intermediate Mesodermal Cell Differentiation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Positive Regulation Of Cardiac Muscle Fiber Development Negative Regulation Of Glomerulus Development Kinase Binding Glucose Transporter Complex Histone H3K4 Dimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity Apoptotic Process Involved In Heart Morphogenesis Positive Regulation Of MiRNA Processing Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Positive Regulation Of Primary MiRNA Processing Bronchus Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Deltoid Tuberosity Development Tendon Cell Differentiation Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Jelly Development Negative Regulation Of Immature T Cell Proliferation Prostate Gland Morphogenesis Epithelial-mesenchymal Cell Signaling Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Branching Involved In Lung Morphogenesis Telencephalon Regionalization Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Glomerular Capillary Formation Pericyte Cell Differentiation Specification Of Animal Organ Position Trachea Development Regulation Of Prostatic Bud Formation Mesodermal Cell Fate Determination Prostatic Bud Formation Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Lens Induction In Camera-type Eye Mammary Gland Formation Negative Regulation Of Prostatic Bud Formation Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Muscular Septum Morphogenesis Response To Aroclor 1254 Dendritic Spine Head Response To Ketamine Response To Thyroglobulin Triiodothyronine	Protein Folding In Endoplasmic Reticulum Perinuclear Region Of Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Protein Stability Small Protein Activating Enzyme Binding Protein Stabilization MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Catalytic Activity Protein Modification Process Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cell Communication Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-7 Response To Interleukin-7 Post-translational Protein Modification Protein Folding Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Transcription Factor Binding Positive Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transport Chemokine Receptor Activity Protein Modification By Small Protein Conjugation Endoplasmic Reticulum Quality Control Compartment Negative Regulation Of RNA Biosynthetic Process Regulation Of Lymphocyte Chemotaxis Unfolded Protein Binding Negative Regulation Of Transporter Activity Protein Metabolic Process Presynaptic Cytosol Peptide Binding Postsynaptic Cytosol Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic