CHP1 and SLC9A4

Number of citations of the paper that reports this interaction (PubMedID 12576672)
0

Data Source:
HPRD (in vitro, in vivo)

		CHP1	SLC9A4
Description		calcineurin like EF-hand protein 1	solute carrier family 9 member A4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytoskeleton Plasma Membrane Focal Adhesion Endomembrane System Microtubule Cytoskeleton Membrane Transport Vesicle Membrane Raft Extracellular Exosome Transporter Complex	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Zymogen Granule Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Sodium:proton Antiporter Activity Potassium Channel Regulator Activity Kinase Binding Metal Ion Binding Calcium-dependent Protein Binding	Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity
	Biological Process	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase-mediated Signal Transduction Negative Regulation Of Phosphatase Activity Protein Transport Membrane Docking Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Sodium Ion Transmembrane Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane	Gastric Acid Secretion Glandular Epithelial Cell Development Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Regulation Of Intracellular PH Transmembrane Transport Transepithelial Ammonium Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Hyaluronan degradation	Sodium/Proton exchangers
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Basophil count ( 32888494) Bisphosphonate-associated atypical femoral fracture ( 31006051) Celiac disease ( 25920553 30572963 18311140) Crohn's disease ( 28067908) Delirium ( 29631748) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Night sleep phenotypes ( 27126917) Serum protein levels (sST2) ( 23999434) White blood cell types ( 21738478)
Interacting Genes		10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC	2 interacting genes: CHP1 CHP2
Entrez ID		11261	389015
HPRD ID		06101	15973
Ensembl ID		ENSG00000187446	ENSG00000180251
Uniprot IDs		H0YKE7 Q99653	Q6AI14
PDB IDs		2E30 7DSV 7DSX 7X2U
Enriched GO Terms of Interacting Partners?		Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Apical Plasma Membrane Chemical Homeostasis Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Recycling Endosome Membrane Membrane Peptidyl-cysteine S-nitrosylase Activity Peptidyl-cysteine S-nitrosylation GAIT Complex Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Retrograde Neuronal Dense Core Vesicle Transport Glandular Epithelial Cell Development Extracellular Exosome Aspartic-type Endopeptidase Inhibitor Activity	Regulation Of Phosphatase Activity Regulation Of Dephosphorylation Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Import Into Nucleus Regulation Of Calcium-mediated Signaling Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Transport Regulation Of Intracellular Transport Negative Regulation Of Phosphatase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Glycosylation Transporter Complex Positive Regulation Of Phosphatase Activity Positive Regulation Of Protein Localization Negative Regulation Of Dephosphorylation Regulation Of Protein Transport Positive Regulation Of Dephosphorylation Regulation Of Protein Glycosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Calcium Ion Binding Positive Regulation Of Phospholipid Biosynthetic Process Sodium:proton Antiporter Activity Regulation Of Protein Autophosphorylation Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Transport Negative Regulation Of Calcium-mediated Signaling Regulation Of Protein Localization Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane Cellular Response To PH Regulation Of Protein Targeting To Membrane Positive Regulation Of Sodium Ion Transport Protein Export From Nucleus
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