CHP1 and PRSS23

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHP1	PRSS23
Description		calcineurin like EF-hand protein 1	serine protease 23
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytoskeleton Plasma Membrane Focal Adhesion Endomembrane System Microtubule Cytoskeleton Membrane Transport Vesicle Membrane Raft Extracellular Exosome Transporter Complex	Extracellular Region Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Sodium:proton Antiporter Activity Potassium Channel Regulator Activity Kinase Binding Metal Ion Binding Calcium-dependent Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase-mediated Signal Transduction Negative Regulation Of Phosphatase Activity Protein Transport Membrane Docking Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Sodium Ion Transmembrane Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane	Proteolysis
Pathways		Hyaluronan degradation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 28869591 30598549) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC	27 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4 UBC
Entrez ID		11261	11098
HPRD ID		06101	07149
Ensembl ID		ENSG00000187446	ENSG00000150687
Uniprot IDs		H0YKE7 Q99653	O95084
PDB IDs		2E30 7DSV 7DSX 7X2U
Enriched GO Terms of Interacting Partners?		Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Apical Plasma Membrane Chemical Homeostasis Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Recycling Endosome Membrane Membrane Peptidyl-cysteine S-nitrosylase Activity Peptidyl-cysteine S-nitrosylation GAIT Complex Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Retrograde Neuronal Dense Core Vesicle Transport Glandular Epithelial Cell Development Extracellular Exosome Aspartic-type Endopeptidase Inhibitor Activity
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