CHP1 and SLC9A1

Number of citations of the paper that reports this interaction (PMID 8901634)
31

Data Source:
HPRD (in vivo, in vitro)

		CHP1	SLC9A1
Gene Name		calcineurin-like EF-hand protein 1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion Microtubule Cytoskeleton Transport Vesicle Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cation-transporting ATPase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Transporter Activity Calcium Ion Binding Protein Binding Microtubule Binding Potassium Channel Regulator Activity Kinase Binding Calcium-dependent Protein Binding	Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Solute:proton Antiporter Activity Sodium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein Binding, Bridging Protein Complex Scaffold Calcium-dependent Protein Binding Sodium:proton Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential
	Biological Process	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Carbohydrate Metabolic Process Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase Mediated Signal Transduction Pathogenesis Negative Regulation Of Phosphatase Activity Calcium Ion-dependent Exocytosis Membrane Docking Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Import Into Nucleus Small Molecule Metabolic Process Transcytosis Protein Stabilization Positive Regulation Of Protein Transport Protein Oligomerization Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Death	Carbohydrate Metabolic Process Ion Transport Cellular Sodium Ion Homeostasis Regulation Of PH Pathogenesis Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Growth Cell Migration Maintenance Of Cell Polarity Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Focal Adhesion Assembly Regulation Of Sensory Perception Of Pain Cardiac Muscle Cell Differentiation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Neuron Death Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Sodium Ion Export Cellular Response To Hypoxia Cellular Response To Acidic PH Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Hydrogen Ion Transmembrane Transport Positive Regulation Of Calcium:sodium Antiporter Activity
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism SLC-mediated transmembrane transport Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Sodium/Proton exchangers Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs			Amiloride Homoserine Lactone
Diseases
GWAS
Protein-Protein Interactions		9 interactors: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B	12 interactors: CA2 CHP1 CHP2 DAXX MAP4K4 MAPK1 MAPK14 MDFI TESC TNIK WNK1 YWHAB
Entrez ID		11261	6548
HPRD ID		06101	00123
Ensembl ID		ENSG00000187446	ENSG00000090020
Uniprot IDs		H0YKE7 Q99653	B2RAH2 P19634
PDB IDs		2E30	1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2YGG
Enriched GO Terms of Interacting Partners?		Regulation Of PH Hydrogen Ion Transmembrane Transport Sodium Ion Transmembrane Transport Proton Transport Sodium Ion Transport Ion Homeostasis Monovalent Inorganic Cation Transport Metal Ion Transport Chemical Homeostasis Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Neuron Death Sodium Ion Import Across Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Cell Death Death Sodium Ion Import Cardiac Muscle Cell Contraction Regulation Of The Force Of Heart Contraction By Cardiac Conduction Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of The Force Of Heart Contraction Peptidyl-cysteine S-nitrosylation Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Pathogenesis Sodium Ion Export Positive Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Acidic PH Positive Regulation Of Action Potential Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Transport Gastric Acid Secretion Cellular Response To Electrical Stimulus Maintenance Of Cell Polarity Regulation Of Calcineurin-NFAT Signaling Cascade Apoptotic Process Cellular Sodium Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Hyaluronan Catabolic Process Programmed Cell Death Mitochondrion Transport Along Microtubule Cellular Response To PH Positive Regulation Of Sodium Ion Transmembrane Transport Establishment Of Mitochondrion Localization Cellular Response To Epinephrine Stimulus	Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation MAPK Cascade Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cellular Localization Cellular Response To Stimulus Regulation Of Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Dephosphorylation Regulation Of Establishment Of Protein Localization Phosphorylation Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Negative Regulation Of Transport Regulation Of JNK Cascade Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Transport Positive Regulation Of Phosphorylation Regulation Of Protein Localization To Nucleus Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport
Tagcloud ?		antisilencing associating chromodomain clr4 comprise coordinates determinant disrupted dissecting dsr eliminating epe1 facultative fission follows h3k9 heterochromatin machinery mechanistically mei4 meiotic mmi1 participates recruits red1 reversibly ssm4 suv39h transacting	atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc4 slc4a7 summarize transporters unifying
Tagcloud (Difference) ?		antisilencing associating chromodomain clr4 comprise coordinates determinant disrupted dissecting dsr eliminating epe1 facultative fission follows h3k9 heterochromatin machinery mechanistically mei4 meiotic mmi1 participates recruits red1 reversibly ssm4 suv39h transacting	atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc4 slc4a7 summarize transporters unifying
Tagcloud (Intersection) ?