CHP1 and SLC9A5

Number of citations of the paper that reports this interaction (PubMedID 12576672)
0

Data Source:
HPRD (in vitro, in vivo)

		CHP1	SLC9A5
Description		calcineurin like EF-hand protein 1	solute carrier family 9 member A5
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytoskeleton Plasma Membrane Focal Adhesion Endomembrane System Microtubule Cytoskeleton Membrane Transport Vesicle Membrane Raft Extracellular Exosome Transporter Complex	Endosome Plasma Membrane Focal Adhesion Membrane Dendritic Spine Membrane Cell Projection Neuron Spine Synapse Postsynaptic Membrane Recycling Endosome Membrane Anchoring Junction Synaptic Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Sodium:proton Antiporter Activity Potassium Channel Regulator Activity Kinase Binding Metal Ion Binding Calcium-dependent Protein Binding	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Arrestin Family Protein Binding
	Biological Process	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase-mediated Signal Transduction Negative Regulation Of Phosphatase Activity Protein Transport Membrane Docking Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Sodium Ion Transmembrane Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Hyaluronan degradation	Sodium/Proton exchangers
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	A body shape index ( 34021172) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC	5 interacting genes: ARRB1 ARRB2 CHP1 CHP2 RACK1
Entrez ID		11261	6553
HPRD ID		06101	02723
Ensembl ID		ENSG00000187446	ENSG00000135740
Uniprot IDs		H0YKE7 Q99653	Q14940
PDB IDs		2E30 7DSV 7DSX 7X2U
Enriched GO Terms of Interacting Partners?		Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Apical Plasma Membrane Chemical Homeostasis Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Recycling Endosome Membrane Membrane Peptidyl-cysteine S-nitrosylase Activity Peptidyl-cysteine S-nitrosylation GAIT Complex Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Retrograde Neuronal Dense Core Vesicle Transport Glandular Epithelial Cell Development Extracellular Exosome Aspartic-type Endopeptidase Inhibitor Activity	Angiotensin Receptor Binding Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Protein Ubiquitination Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Adaptation Of Signaling Pathway Regulation Of Phosphatase Activity G Protein-coupled Receptor Internalization Regulation Of Phosphorus Metabolic Process Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Molecular Adaptor Activity Regulation Of Protein Ubiquitination Regulation Of Dephosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Internalization Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Transport Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Endocytosis Positive Regulation Of Establishment Of Protein Localization Protein Transport Negative Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Modification Process Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Phosphorylation Enzyme Binding Regulation Of Protein Import Into Nucleus Establishment Of Protein Localization Regulation Of Phosphorylation Receptor Internalization Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Protein Localization Regulation Of Protein Transport Endocytic Vesicle Membrane G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Receptor Internalization
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