SLC6A8 and BDKRB1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		SLC6A8	BDKRB1
Name		solute carrier family 6 member 8	bradykinin receptor B1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Creatine Transmembrane Transporter Activity Creatine:sodium Symporter Activity Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Symporter Activity Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Creatine Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Amino Acid Transport Muscle Contraction Gamma-aminobutyric Acid Transport Creatine Transmembrane Transport Sodium Ion Transmembrane Transport	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Creatine metabolism	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Creatine Phosphocreatine	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Non-syndromic X-linked mental retardation Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)	None
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 )
Interacting Genes		3 interacting genes: BDKRB1 CD59 CHRM5	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		6535	623
HPRD ID		02073	02639
Ensembl ID		ENSG00000130821	ENSG00000100739
Uniprot IDs		P48029 Q59EV7 X5D9C4	P46663
PDB IDs		Not available	7EIB
GO Terms Enriched among Interactors		Regulation Of Phospholipid Metabolic Process Bradykinin Receptor Activity Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Activation Of Membrane Attack Complex G Protein-coupled Acetylcholine Receptor Activity Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling Positive Regulation Of Cardiolipin Metabolic Process 1-acylglycerophosphocholine O-acyltransferase Activity Complement Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process Cristae Formation Regulation Of Complement Activation Regulation Of Dephosphorylation G Protein-coupled Acetylcholine Receptor Signaling Pathway Transmission Of Nerve Impulse Dopamine Transport 1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Regulation Of ATP Biosynthetic Process Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Acid Secretion Regulation Of Phosphorus Metabolic Process Peptide Binding Monoamine Transport Phosphatidylglycerol Metabolic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ATP Metabolic Process Inner Mitochondrial Membrane Organization Protein Sequestering Activity Acetylcholine Receptor Signaling Pathway Negative Regulation Of Blood Pressure Regulation Of Humoral Immune Response Postsynaptic Signal Transduction G Protein-coupled Receptor Signaling Pathway Complement Activation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding